Artículo
Endoglin in the spotlight to treat cáncer
Autor/es | González Muñoz, Teresa
Amaral, Ana Teresa Puerto-Camacho, Pilar Peinado, Héctor Álava Casado, Enrique de |
Departamento | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica |
Fecha de publicación | 2021-03-20 |
Fecha de depósito | 2021-05-21 |
Publicado en |
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Resumen | A spotlight has been shone on endoglin in recent years due to that fact of its potential to serve as both a reliable disease biomarker and a therapeutic target. Indeed, endoglin has now been assigned many roles in both ... A spotlight has been shone on endoglin in recent years due to that fact of its potential to serve as both a reliable disease biomarker and a therapeutic target. Indeed, endoglin has now been assigned many roles in both physiological and pathological processes. From a molecular point of view, endoglin mainly acts as a co-receptor in the canonical TGFβ pathway, but also it may be shed and released from the membrane, giving rise to the soluble form, which also plays important roles in cell signaling. In cancer, in particular, endoglin may contribute to either an oncogenic or a non-oncogenic phenotype depending on the cell context. The fact that endoglin is expressed by neoplastic and non-neoplastic cells within the tumor microenvironment suggests new possibilities for targeted therapies. Here, we aimed to review and discuss the many roles played by endoglin in different tumor types, as well as the strong evidence provided by pre-clinical and clinical studies that supports the therapeutic targeting of endoglin as a novel clinical strategy. |
Identificador del proyecto | W81XWH-16-1-0131
RTC-2014-2102-1 PI17-000464 |
Cita | González Muñoz, T., Amaral, A.T., Puerto-Camacho, P., Peinado, H. y Álava, E.d. (2021). Endoglin in the spotlight to treat cáncer. Revista International Journal of Molecular Sciences, 22 (6) |
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