Perfil del autor: Álava Casado, Enrique de
Datos institucionales
| Nombre | Álava Casado, Enrique de |
| Departamento | Citología e Histología Normal y Patológica |
| Área de conocimiento | Anatomía Patológica |
| Categoría profesional | Profesor Titular de Universidad (Pza. V) |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
38
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Nº visitas
2410
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Nº descargas
1515
| Publicaciones |
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Artículo
 VE-Cadherin modulates β-catenin/TCF-4 to enhance vasculogenic mimicry
(Nature Publishing Group, 2023)
Vasculogenic Mimicry (VM) refers to the capacity to form a blood network from aggressive cancer cells in an independent ... |
Artículo
Ewing Sarcoma Meets Epigenetics, Immunology and Nanomedicine: Moving Forward into Novel Therapeutic Strategies
(MDPI, 2022)
Ewing Sarcoma (EWS) is an aggressive bone and soft tissue tumor that mainly affects children, adolescents, and young adults. ... |
Artículo
Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastoma
(Springer, 2022)
The majority of current cancer therapies are aimed at reducing tumour growth, but there is lack of viable pharmacological ... |
Artículo
An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma
(Nature Research, 2022)
The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized ... |
Artículo
Genetic alterations and deregulation of hippo pathway as a pathogenetic mechanism in bone and soft tissue sarcoma
(MDPI, 2022)
The Hippo pathway is an evolutionarily conserved modulator of developmental biology with a key role in tissue and organ ... |
Artículo
Endoglin and MMP14 Contribute to Ewing Sarcoma Spreading by Modulation of Cell–Matrix Interactions
(MDPI ; MDPI AG, 2022)
Abstract: Endoglin (ENG) is a mesenchymal stem cell (MSC) marker typically expressed by active endothelium. This transmembrane ... |
Artículo
Cost-effectiveness analysis of molecular diagnosis by next-generation sequencing versus sequential single testing in metastatic non-small cell lung cancer patients from a south Spanish hospital perspective
(Taylor and Francis LTD, 2022)
Background: To assess the cost-effectiveness of using next-generation sequencing (NGS) compared to sequential single-testing ... |
Artículo
 Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1
(Nature Publishing Group, 2022)
Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor with high susceptibility to metastasize. The underlying ... |
Artículo
Evaluation of NAB2-STAT6 Fusion Variants and Other Molecular Alterations as Prognostic Biomarkers in a Case Series of 83 Solitary Fibrous Tumors
(MDPI, 2021)
Risk stratification of solitary fibrous tumor (SFT) patients based on clinicopathological features has limited efficacy, ... |
Tesis Doctoral
Endoglin in Ewing sarcoma: from the biological relevance to a clinical strategy
(2021)
Endoglin (ENG) is a mesenchymal stem cell (MSC) marker highly expressed mainly in active endothelium and certain cancer ... |
Artículo
Ewing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives
(MDPI, 2021)
Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime example of the paradigms of a ... |
Artículo
Endoglin in the spotlight to treat cáncer
(MDPI, 2021)
A spotlight has been shone on endoglin in recent years due to that fact of its potential to serve as both a reliable disease ... |
Artículo
Multidisciplinary consensus on optimising the detection of NTRK gene alterations in tumours
(Springer, 2021)
The recent identification of rearrangements of neurotrophic tyrosine receptor kinase (NTRK) genes and the development ... |
Artículo
The bitter side of epigenetics: variability and resistance to chemotherapy
(Future Medicine, 2021)
One of the major obstacles to the development of effective new cancer treatments and the main factor for the increasing ... |
Artículo
Molecular diagnosis in non-small-cell lung cancer: expert opinion on ALK and ROS1 testing
(BMJ Publishing Group, 2021)
The effectiveness of targeted therapies with tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC) depends on ... |
Artículo
Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions
(Elsevier, 2021)
Background: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/ activity ... |
Artículo
Molecular diagnosis in non-small-cell lung cancer: expert opinion on ALK and ROS1 testing
(BMJ Publishing Group, 2021)
The effectiveness of targeted therapies with tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC) depends ... |
Artículo
Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma
(Frontiers Media, 2021)
The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. ... |
Artículo
Sarcoma classification by DNA methylation profiling
(Nature Publishing Ggroup, 2021)
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically ... |
Artículo
Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts
(Elsevier, 2021)
Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ... |
Artículo
Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
(Springer Nature, 2021)
Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver ... |
Artículo
RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis
(American Association for the Advancement of Science, 2020)
Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal ... |
Artículo
An inducible ectopic expression system of EWSR1-FLI1 as a tool for understanding Ewing sarcoma oncogénesis
(Public Library of Science, 2020)
The presence of the chimeric EWSR1-FLI1 oncoprotein is the main and initiating event defining Ewing sarcoma (ES). The ... |
Artículo
Hippo pathway effectors YAP1/TAZ induce an EWS-FLI1-opposing gene signature and associate with disease progression in Ewing sarcoma
(Wiley, 2020)
YAP1 and TAZ (WWTR1) oncoproteins are thefinal transducers of the Hippo tumor suppressor pathway. Deregula-tion of the ... |
Artículo
Synergistic Enhancement of Cancer Therapy Using HDAC Inhibitors: Opportunity for Clinical Trials
(Frontiers Media S.A., 2020)
Chemotherapy is one of the most established and effective treatments for almost all types of cancer. However, the elevated ... |
Artículo
From precision medicine to imprecision medicine through limited diagnostic ability to detect low allelic frequency mutations
(2020)
Routine molecular testing in NSCLC is currently moving beyond the classical EGFR mutational analysis and the evolving ... |
Artículo
Nivolumab and sunitinib combination in advanced soft tissue sarcomas: a multicenter, single-arm, phase Ib/II trial
(BMJ Journals, 2020)
Background: Sarcomas exhibit low expression of factors related to immune response, which could explain the modest activity ... |
Artículo
Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape
(MDPI, 2020)
Ewing sarcoma is a highly aggressive round cell mesenchymal neoplasm, most often occurring in children and young adults. ... |
Artículo
Clinical performance evaluation of the Idylla (TM) EGFR Mutation Test on formalin-fixed paraffin-embedded tissue of non-small cell lung cáncer
(BMC, 2020)
Background: Detection of epidermal growth factor receptor (EGFR) mutations in exons 18-21 is recommended in all patients ... |
Artículo
Both Epimutations and Chromosome Aberrations Affect Multiple Imprinted Loci in Aggressive Wilms Tumors
(MDPI, 2020)
The embryonal renal cancer Wilms tumor (WT) accounts for 7% of all children’s malignancies. Its most frequent molecular ... |
Artículo
Liquid biopsy in oncology: a consensus statement of the Spanish Society of Pathology and the Spanish Society of Medical Oncology
(Springer, 2020)
The proportion of cancer patients with tumours that harbour a potentially targetable genomic alteration is growing ... |
Tesis Doctoral
 Estudio de los coactivadores transcripcionales TAZ y YAP1 en el sarcoma de Ewing: Implicación en la progresión tumoral e interacción funcional con la proteína de fusión EWS-FLI1
(2019)
La presente tesis doctoral aborda, por primera vez, el papel funcional de los dos efectores finales de la vía Hippo, TAZ ... |
Artículo
Ciclos de mejora docente integrados en Anatomía Patológica: ¿primer paso hacia una enseñanza integrada?
(Universidad de Sevilla, 2018)
Nuestra hipótesis es que el aprendizaje de los alumnos mejoraría si se integrasen contenidos de diversas asignaturas y se ... |
Artículo
Multidrug resistance transporter profile reveals MDR3 as a marker for stratification of blastemal Wilms tumour patients
(Impact Journals, 2017)
Wilms tumour (WT) is the most common renal tumour in children. Most WT patients respond to chemotherapy, but subsets of ... |
Artículo
HMGA2 overexpression predicts relapse susceptibility of blastemal Wilms tumor patients
(Impact Journals, 2017)
Wilms tumor (WT) is an embryonal malignant neoplasm of the kidney that accounts for 6–7% of all childhood cancers. WT seems ... |
Artículo
Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study
(BMC, 2016)
Background: Most GISTs have mutations in KIT or PDGFRA. Patients with advanced GIST with KIT exon 9, PDGFRA mutation or ... |
Artículo
RING1B contributes to Ewing sarcoma development by repressing the Na(V)1.6 sodium channel and the NF-kappa B pathway, independently of the fusion oncoprotein
(Impact Journals, 2016)
Ewing sarcoma (ES) is an aggressive tumor defined by EWSR1 gene fusions that behave as an oncogene. Here we demonstrate ... |
Artículo
The second European interdisciplinary Ewing sarcoma research summit – A joint effort to deconstructing the multiple layers of a complex disease
(Impact Journals LLC, 2016)
Despite multimodal treatment, long term outcome for patients with Ewing sarcoma is still poor. The second “European ... |