NameÁlava Casado, Enrique de
DepartmentCitología e Histología Normal y Patológica
Knowledge areaAnatomía Patológica
Professional categoryProfesor Titular de Universidad (Pza. V)
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  • No. publications

    38

  • No. visits

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    1559


 

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VE-Cadherin modulates β-catenin/TCF-4 to enhance vasculogenic mimicry

Delgado-Bellido, Daniel; Zamudio-Martínez, Esteban; Fernández-Cortés, Mónica; Herrera-Campos, Ana Belén; Olmedo Pelayo, Joaquín; Jordán Pérez, Carmen; Álava Casado, Enrique de; Oliver, F. J. (Nature Publishing Group, 2023)
Vasculogenic Mimicry (VM) refers to the capacity to form a blood network from aggressive cancer cells in an independent ...
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Ewing Sarcoma Meets Epigenetics, Immunology and Nanomedicine: Moving Forward into Novel Therapeutic Strategies

Sánchez Molina, Sara; Figuerola Bou, Elisabet; Sánchez Margalet, Víctor; Cruz Merino, Luis de la; Mora, Jaume; Álava Casado, Enrique de; García-Domínguez, Daniel J.; Hontecillas Prieto, Lourdes (MDPI, 2022)
Ewing Sarcoma (EWS) is an aggressive bone and soft tissue tumor that mainly affects children, adolescents, and young adults. ...
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Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastoma

Navarro, Natalia; Molist, Carla; Sansa Girona, Júlia; Zarzosa, Patricia; Gallo-Oller, Gabriel; Pons, Guillem; Álava Casado, Enrique de; Roma, Josep (Springer, 2022)
The majority of current cancer therapies are aimed at reducing tumour growth, but there is lack of viable pharmacological ...
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An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma

Shulman, David S.; Whittle, Sarah B.; Surdez, Didier; Bailey, Kelly M.; Álava Casado, Enrique de; Yustein, Jason T.; Grohar, Patrick J. (Nature Research, 2022)
The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized ...
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Genetic alterations and deregulation of hippo pathway as a pathogenetic mechanism in bone and soft tissue sarcoma

Salguero-Aranda, Carmen; Olmedo Pelayo, Joaquín; Álava Casado, Enrique de; Amaral, Ana Teresa; Díaz-Martín, Juan (MDPI, 2022)
The Hippo pathway is an evolutionarily conserved modulator of developmental biology with a key role in tissue and organ ...
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Endoglin and MMP14 Contribute to Ewing Sarcoma Spreading by Modulation of Cell–Matrix Interactions

Puerto-Camacho, Pilar; Díaz-Martín, Juan; Olmedo Pelayo, Joaquín; Bolado Carrancio, Alfonso; Salguero-Aranda, Carmen; Jordán-Pérez, Carmen; Álava Casado, Enrique de (MDPI ; MDPI AG, 2022)
Abstract: Endoglin (ENG) is a mesenchymal stem cell (MSC) marker typically expressed by active endothelium. This transmembrane ...
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Cost-effectiveness analysis of molecular diagnosis by next-generation sequencing versus sequential single testing in metastatic non-small cell lung cancer patients from a south Spanish hospital perspective

Álava Casado, Enrique de; Pareja, María Jesús; Carcedo, David; Arrabal, Natalia; García, José-Francisco; Bernabé-Caro, Reyes (Taylor and Francis LTD, 2022)
Background: To assess the cost-effectiveness of using next-generation sequencing (NGS) compared to sequential single-testing ...
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Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1

García-Domínguez, Daniel J.; Hajji, Nabil; López Alemany, Roser; Sánchez Molina, Sara; Figuerola Bou, Elisabet; Morón Civanto, Francisco Jesús; Álava Casado, Enrique de; Hontecillas Prieto, Lourdes (Nature Publishing Group, 2022)
Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor with high susceptibility to metastasize. The underlying ...
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Evaluation of NAB2-STAT6 Fusion Variants and Other Molecular Alterations as Prognostic Biomarkers in a Case Series of 83 Solitary Fibrous Tumors

Salguero-Aranda, Carmen; Martínez-Reguera, Paula; Marcilla, David; Álava Casado, Enrique de; Díaz Martín, Juan (MDPI, 2021)
Risk stratification of solitary fibrous tumor (SFT) patients based on clinicopathological features has limited efficacy, ...
PhD Thesis
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Endoglin in Ewing sarcoma: from the biological relevance to a clinical strategy

Puerto-Camacho, Pilar; Álava Casado, Enrique de; Monteiro Amaral, Ana Teresa (2021)
Endoglin (ENG) is a mesenchymal stem cell (MSC) marker highly expressed mainly in active endothelium and certain cancer ...
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Ewing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives

Zöllner, Stefan K.; Amatruda, James F.; Bauer, Sebastian; Collaud, Stéphane; Álava Casado, Enrique de; Dubois, Steven G.; Dirksen, Uta (MDPI, 2021)
Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime example of the paradigms of a ...
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Endoglin in the spotlight to treat cáncer

González Muñoz, Teresa; Amaral, Ana Teresa; Puerto-Camacho, Pilar; Peinado, Héctor; Álava Casado, Enrique de (MDPI, 2021)
A spotlight has been shone on endoglin in recent years due to that fact of its potential to serve as both a reliable disease ...
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Multidisciplinary consensus on optimising the detection of NTRK gene alterations in tumours

Garrido, P.; Hladun, R.; Álava Casado, Enrique de; Álvarez, R.; Bautista, F.; López-Ríos, F.; Colomer, R.; Rojo, F. (Springer, 2021)
The recent identification of rearrangements of neurotrophic tyrosine receptor kinase (NTRK) genes and the development ...
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The bitter side of epigenetics: variability and resistance to chemotherapy

Hajji, Nabil; García-Domínguez, Daniel J.; Hontecillas Prieto, Lourdes; O'Neill, Kevin; Álava Casado, Enrique de; Syed, Nelofer (Future Medicine, 2021)
One of the major obstacles to the development of effective new cancer treatments and the main factor for the increasing ...
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Molecular diagnosis in non-small-cell lung cancer: expert opinion on ALK and ROS1 testing

Conde, Esther; Rojo, Federico; Gómez, Javier; Enguita, Ana Belén; Abdulkader, Ihab; González, Ana; Lozano, Dolores; Álava Casado, Enrique de (BMJ Publishing Group, 2021)
The effectiveness of targeted therapies with tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC) depends on ...
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Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Martí, Juan Manuel; Garcia-Diaz, Angel; Delgado-Bellido, Daniel; O'Valle, Francisco; González-Flores, Ariannys; Carlevaris, Onintza; Álava Casado, Enrique de; Oliver, F. Javier (Elsevier, 2021)
Background: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/ activity ...
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Molecular diagnosis in non-small-cell lung cancer: expert opinion on ALK and ROS1 testing

Conde, Esther; Rojo, Federico; Gómez, Javier; Enguita, Ana Belén; Abdulkader, Ihab; González, Ana; Álava; Álava Casado, Enrique de (BMJ Publishing Group, 2021)
The effectiveness of targeted therapies with tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC) depends ...
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Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma

Sanegre, Sabina; Eritja, Núria; Andrea, Carlos de; Díaz-Martín, Juan; Díaz-Lagares, Ángel; Jácome, María Amalia; Salguero-Aranda, Carmen; Álava Casado, Enrique de; Noguera, Rosa (Frontiers Media, 2021)
The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. ...
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Sarcoma classification by DNA methylation profiling

Koelsche, Christian; Schrimpf, Daniel; Stichel, Damian; Sill, Martin; Sahm, Felix; Reuss, David E.; Romero Pérez, Laura; Álava Casado, Enrique de; Idoate Gastearena, Miguel Ángel; Hohenberger, Peter (Nature Publishing Ggroup, 2021)
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically ...
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Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts

Stacchiotti, S.; Miah, A. B.; Frezza, A. M.; Messiou, C.; Morosi, C.; Caraceni, A.; Álava Casado, Enrique de; Gronchi, A. (Elsevier, 2021)
Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ...
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Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma

García-Domínguez, Daniel J.; Hajji, Nabil; Sánchez Molina, Sara; Figuerola Bou, Elisabet; Martínez de Pablos, Rocío; Espinosa Oliva, Ana María; Flores Campos, Rocío; Robles Frías, María José; Álava Casado, Enrique de; Hontecillas Prieto, Lourdes (Springer Nature, 2021)
Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver ...
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RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis

Sánchez Molina, Sara; Figuerola Bou, Elisabet; Blanco, Enrique; Sánchez Jiménez, María; Táboas, Pablo; Gómez, Soledad; Álava Casado, Enrique de (American Association for the Advancement of Science, 2020)
Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal ...
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An inducible ectopic expression system of EWSR1-FLI1 as a tool for understanding Ewing sarcoma oncogénesis

García-Domínguez, Daniel J.; Hontecillas-Prieto, Lourdes; Andrés León, Eduardo; Sánchez-Molina, Sara; Rodríguez-Núñez, Pablo; Morón, Francisco J.; Hajji, Nabil; Mackintosh, Carlos; Álava Casado, Enrique de (Public Library of Science, 2020)
The presence of the chimeric EWSR1-FLI1 oncoprotein is the main and initiating event defining Ewing sarcoma (ES). The ...
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Hippo pathway effectors YAP1/TAZ induce an EWS-FLI1-opposing gene signature and associate with disease progression in Ewing sarcoma

Rodríguez-Núñez, Pablo; Romero Pérez, Laura; Amaral, Ana T.; Puerto-Camacho, Pilar; Jordán, Carmen; Marcilla, David; Álava Casado, Enrique de; Díaz-Martín, Juan (Wiley, 2020)
YAP1 and TAZ (WWTR1) oncoproteins are thefinal transducers of the Hippo tumor suppressor pathway. Deregula-tion of the ...
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Synergistic Enhancement of Cancer Therapy Using HDAC Inhibitors: Opportunity for Clinical Trials

Hontecillas Prieto, Lourdes; Flores Campos, Rocío; Silver, Andrew; Álava Casado, Enrique de; Hajji, Nabil; García-Domínguez, Daniel J. (Frontiers Media S.A., 2020)
Chemotherapy is one of the most established and effective treatments for almost all types of cancer. However, the elevated ...
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From precision medicine to imprecision medicine through limited diagnostic ability to detect low allelic frequency mutations

Serrano, María José; Expósito Hernández, José; Guerrero, Rosa; López Hidalgo, Javier; Aguilar, Mariano; Lorente, José Antonio; Álava Casado, Enrique de; Garrido Navas, María del Carmen (2020)
Routine molecular testing in NSCLC is currently moving beyond the classical EGFR mutational analysis and the evolving ...
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Nivolumab and sunitinib combination in advanced soft tissue sarcomas: a multicenter, single-arm, phase Ib/II trial

Martín Broto, Javier; Hindi, Nadia; Grignani, Giovanni; Martínez Trufero, Javier; Redondo, Andrés; Valverde, Claudia; Encinas Tobajas, Víctor; Álava Casado, Enrique de; López Martín, José A. (BMJ Journals, 2020)
Background: Sarcomas exhibit low expression of factors related to immune response, which could explain the modest activity ...
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Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape

Salguero-Aranda, Carmen; Amaral, Ana Teresa; Olmedo Pelayo, Joaquín; Diaz-Martin, Juan; Álava Casado, Enrique de (MDPI, 2020)
Ewing sarcoma is a highly aggressive round cell mesenchymal neoplasm, most often occurring in children and young adults. ...
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Clinical performance evaluation of the Idylla (TM) EGFR Mutation Test on formalin-fixed paraffin-embedded tissue of non-small cell lung cáncer

Delgado-García, Mercedes; Weynand, Birgit; Gómez-Izquierdo, Lourdes; Hernández, María José; Blanco, Ángela María; Varela, Mar; Álava Casado, Enrique de; Biscuola, Michele (BMC, 2020)
Background: Detection of epidermal growth factor receptor (EGFR) mutations in exons 18-21 is recommended in all patients ...
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Both Epimutations and Chromosome Aberrations Affect Multiple Imprinted Loci in Aggressive Wilms Tumors

Pignata, Laura; Palumbo, Orazio; Cerrato, Flavia; Acurzio, Basilia; Álava Casado, Enrique de; Roma, Josep; Verde, Gaetano (MDPI, 2020)
The embryonal renal cancer Wilms tumor (WT) accounts for 7% of all children’s malignancies. Its most frequent molecular ...
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Liquid biopsy in oncology: a consensus statement of the Spanish Society of Pathology and the Spanish Society of Medical Oncology

Remon, J.; García-Campelo, R.; Álava Casado, Enrique de; Vera, R.; Rodríguez-Peralto, J. L.; Rodríguez-Lescure, Á (Springer, 2020)
The proportion of cancer patients with tumours that harbour a potentially targetable genomic alteration is growing ...
PhD Thesis
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Estudio de los coactivadores transcripcionales TAZ y YAP1 en el sarcoma de Ewing: Implicación en la progresión tumoral e interacción funcional con la proteína de fusión EWS-FLI1

Rodríguez Núñez, Pablo; Álava Casado, Enrique de; Díaz Martín, Juan; García-Domínguez, Daniel J. (2019)
La presente tesis doctoral aborda, por primera vez, el papel funcional de los dos efectores finales de la vía Hippo, TAZ ...
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Ciclos de mejora docente integrados en Anatomía Patológica: ¿primer paso hacia una enseñanza integrada?

Álava Casado, Enrique de (Universidad de Sevilla, 2018)
Nuestra hipótesis es que el aprendizaje de los alumnos mejoraría si se integrasen contenidos de diversas asignaturas y se ...
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Multidrug resistance transporter profile reveals MDR3 as a marker for stratification of blastemal Wilms tumour patients

Hontecillas Prieto, Lourdes; García-Domínguez, Daniel J.; Pascual Vaca, Diego; García Mejías, Rosa; Marcilla, David; Ramírez Villar, Gema; Álava Casado, Enrique de (Impact Journals, 2017)
Wilms tumour (WT) is the most common renal tumour in children. Most WT patients respond to chemotherapy, but subsets of ...
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HMGA2 overexpression predicts relapse susceptibility of blastemal Wilms tumor patients

Hontecillas Prieto, Lourdes; García-Domínguez, Daniel J.; García Mejías, Rosa; Ramírez Villar, Gema; Sáez, Carmen; Álava Casado, Enrique de (Impact Journals, 2017)
Wilms tumor (WT) is an embryonal malignant neoplasm of the kidney that accounts for 6–7% of all childhood cancers. WT seems ...
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Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study

Maurel, Joan; López-Pousa, Antonio; Calabuig, Silvia; Bagué, Silvia; García del Muro, Xavier; Sanjuan, Xavier; Álava Casado, Enrique de (BMC, 2016)
Background: Most GISTs have mutations in KIT or PDGFRA. Patients with advanced GIST with KIT exon 9, PDGFRA mutation or ...
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RING1B contributes to Ewing sarcoma development by repressing the Na(V)1.6 sodium channel and the NF-kappa B pathway, independently of the fusion oncoprotein

Hernández Muñoz, Inmaculada; Figuerola, Elisabeth; Sánchez Molina, Sara; Rodríguez, Eva; Fernández Mariño, María Isabel; Pardo Pastor, Carlos; Álava Casado, Enrique de; Mora, Jaume (Impact Journals, 2016)
Ewing sarcoma (ES) is an aggressive tumor defined by EWSR1 gene fusions that behave as an oncogene. Here we demonstrate ...
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The second European interdisciplinary Ewing sarcoma research summit – A joint effort to deconstructing the multiple layers of a complex disease

Kovar, Heinrich; Amatruda, James; Brunet, Erika; Burdach, Stefan; Cidre-Aranaz, Florencia; Álava Casado, Enrique de (Impact Journals LLC, 2016)
Despite multimodal treatment, long term outcome for patients with Ewing sarcoma is still poor. The second “European ...