Ewing Sarcoma (EWS) is an aggressive bone and soft tissue tumor that mainly affects children, adolescents, and young adults. ...

The majority of current cancer therapies are aimed at reducing tumour growth, but there is lack of viable pharmacological ...

The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized ...

Abstract: Endoglin (ENG) is a mesenchymal stem cell (MSC) marker typically expressed by active endothelium. This transmembrane ...

The Hippo pathway is an evolutionarily conserved modulator of developmental biology with a key role in tissue and organ ...

Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor with high susceptibility to metastasize. The underlying ...

Risk stratification of solitary fibrous tumor (SFT) patients based on clinicopathological features has limited efficacy, ...

Endoglin (ENG) is a mesenchymal stem cell (MSC) marker highly expressed mainly in active endothelium and certain cancer ...

Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime example of the paradigms of a ...

A spotlight has been shone on endoglin in recent years due to that fact of its potential to serve as both a reliable disease ...

The recent identification of rearrangements of neurotrophic tyrosine receptor kinase (NTRK) genes and the development ...

The effectiveness of targeted therapies with tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC) depends ...

One of the major obstacles to the development of effective new cancer treatments and the main factor for the increasing ...

The effectiveness of targeted therapies with tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC) depends on ...

Background: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/ activity ...

The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. ...

Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically ...

Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ...

Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver ...

Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal ...

Ewing sarcoma is a highly aggressive round cell mesenchymal neoplasm, most often occurring in children and young adults. ...

Background: Detection of epidermal growth factor receptor (EGFR) mutations in exons 18-21 is recommended in all patients ...

The proportion of cancer patients with tumours that harbour a potentially targetable genomic alteration is growing ...

The embryonal renal cancer Wilms tumor (WT) accounts for 7% of all children’s malignancies. Its most frequent molecular ...

Background: Sarcomas exhibit low expression of factors related to immune response, which could explain the modest activity ...

Chemotherapy is one of the most established and effective treatments for almost all types of cancer. However, the elevated ...

La presente tesis doctoral aborda, por primera vez, el papel funcional de los dos efectores finales de la vía Hippo, TAZ ...

Nuestra hipótesis es que el aprendizaje de los alumnos mejoraría si se integrasen contenidos de diversas asignaturas y se ...

Wilms tumor (WT) is an embryonal malignant neoplasm of the kidney that accounts for 6–7% of all childhood cancers. WT seems ...

Wilms tumour (WT) is the most common renal tumour in children. Most WT patients respond to chemotherapy, but subsets of ...

Background: Most GISTs have mutations in KIT or PDGFRA. Patients with advanced GIST with KIT exon 9, PDGFRA mutation or ...

Ewing sarcoma (ES) is an aggressive tumor defined by EWSR1 gene fusions that behave as an oncogene. Here we demonstrate ...

Despite multimodal treatment, long term outcome for patients with Ewing sarcoma is still poor. The second “European ...