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Artículo
Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1
(American Society for Microbiology, 2007-06-01)
The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant ...
Artículo
Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes
(American Society for Microbiology, 2006-09-01)
The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 reached intracellular concentrations 10 times higher than the extracellular concentrations reached. ...
Artículo
Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum β-lactamase production
(American Society for Microbiology, 2002-12-01)
The relationships between porin deficiency, active efflux of fluoroquinolones, and extended-spectrum β-lactamase (ESBL) production were determined for 53 clinical isolates of Klebsiella pneumoniae. Thirty-two ESBL-positive ...
Artículo
Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa
(American Society for Microbiology, 2003-07-01)
The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters (SLUCs). This effect was associated with the loss of OprD. The zinc that eluted from SLUCs is ...
Artículo
Uptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cells
(American Society for Microbiology, 2002-12-01)
The intracellular penetration and activity of linezolid in human polymorphonuclear leukocytes and tissue-cultured cells (McCoy) were evaluated. Linezolid reached intracellular concentrations slightly greater than extracellular ...
Artículo
Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes
(American Society for Microbiology, 2000-11-09)
The intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes (PMN) were evaluated. Gemifloxacin reached intracellular concentrations eight times higher than extracellular concentrations. ...
Artículo
Characterization of a clinical isolate of Haemophilus influenzae with a high level of fluoroquinolone resistance
(Oxford University Press, 2006-01-23)
Haemophilus influenzae is one of the bacterial pathogens most likely to be involved in community-acquired respiratory infections in patients with chronic obstructive pulmonary disease. In this species, resistance to ...