dc.creator | García Rodríguez, Néstor | es |
dc.creator | Díaz de la Loza, María del Carmen | es |
dc.creator | Andreson, Bethany | es |
dc.creator | Monje Casas, Fernando | es |
dc.creator | Rothstein, Rodney | es |
dc.creator | Wellinger, Ralf Erik | es |
dc.date.accessioned | 2021-05-12T08:20:33Z | |
dc.date.available | 2021-05-12T08:20:33Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | García Rodríguez, N., Díaz de la Loza, M.d.C., Andreson, B., Monje Casas, F., Rothstein, R. y Wellinger, R.E. (2012). Impaired manganese metabolism causes mitotic misregulation. Journal of Biological Chemistry, 287 (22), 18717-18729. | |
dc.identifier.issn | 0021-9258 (impreso) | es |
dc.identifier.issn | 1083-351X (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/108904 | |
dc.description.abstract | Manganese is an essential trace element, whose intracellular levels need to be carefully regulated. Mn2+ acts as a cofactor for many enzymes and excess of Mn2+ is toxic. Alterations in Mn2+ homeostasis affect metabolic functions and mutations in the human Mn2+/Ca2+ transporter ATP2C1 have been linked to Hailey-Hailey disease. By deletion of the yeast orthologue PMR1 we have studied the impact of Mn2+ on cell cycle progression and show that an excess of cytosolic Mn2+ alters S-phase transit, induces transcriptional up-regulation of cell cycle regulators, bypasses the need for S-phase cell cycle checkpoints and predisposes to genomic instability. On the other hand, we find that depletion of the Golgi Mn2+ pool requires a functional morphology checkpoint to avoid the formation of polyploid cells | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | American Society for Biochemistry and Molecular Biology | es |
dc.relation.ispartof | Journal of Biological Chemistry, 287 (22), 18717-18729. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Impaired manganese metabolism causes mitotic misregulation | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.publisherversion | http://dx.doi.org/10.1074/jbc.M112.358309 | es |
dc.identifier.doi | 10.1074/jbc.M112.358309 | es |
dc.journaltitle | Journal of Biological Chemistry | es |
dc.publication.volumen | 287 | es |
dc.publication.issue | 22 | es |
dc.publication.initialPage | 18717 | es |
dc.publication.endPage | 18729 | es |