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dc.creatorFernández, Raquel Maríaes
dc.creatorPeciña, Anaes
dc.creatorSánchez, Beatrizes
dc.creatorLozano Arana, María Doloreses
dc.creatorGarcía-Lozano, Juan Carloses
dc.creatorPérez Garrido, Rosarioes
dc.creatorAntiñolo Gil, Guillermoes
dc.date.accessioned2021-05-11T16:53:35Z
dc.date.available2021-05-11T16:53:35Z
dc.date.issued2015
dc.identifier.citationFernández, R.M., Peciña, A., Sánchez, B., Lozano Arana, M.D., García-Lozano, J.C., Pérez Garrido, R. y Antiñolo Gil, G. (2015). Experience of Preimplantation Genetic Diagnosis for Hemophilia at the University Hospital Virgen Del Rocío in Spain: Technical and Clinical Overview. BioMed Research International, 2015, art.n.406096.
dc.identifier.issn2314-6133es
dc.identifier.urihttps://hdl.handle.net/11441/108886
dc.description.abstractHemophilia A and B are themost common hereditary hemorrhagic disorders, with an X-linked mode of inheritance. Reproductive options for the families affectedwith hemophilia, aiming at the prevention of the birth of children with severe coagulation disorders, include preimplantation genetic diagnosis (PGD). Here we present the results of our PGD Program applied to hemophilia, at the Department of Genetics, Reproduction and Fetal Medicine of the University Hospital Virgen del Roc´ıo in Seville. A total of 34 couples have been included in our program since 2005 (30 for hemophilia A and 4 for hemophilia B). Overall, 60 cycles were performed, providing a total of 508 embryos. The overall percentage of transfers per cycle was 81.7% and the live birth rate per cycle ranged from10.3 to 24.1% depending on the methodological approach applied. Although PGD for hemophilia can be focused on gender selection of female embryos, our results demonstrate that methodological approaches that allow the diagnosis of the hemophilia status of every embryo have notorious advantages. Our PGD Program resulted in the birth of 12 healthy babies for 10 out of the 34 couples (29.4%), constituting a relevant achievement for the Spanish Public Health System within the field of haematological disorders.es
dc.description.sponsorshipFundacion Pública Andaluza Progreso y Salud (Consejería de Salud) of the Autonomous Government of Andalusia (PI0105-2011)es
dc.formatapplication/pdfes
dc.format.extent8 p.es
dc.language.isoenges
dc.publisherHindawi Publishing Corporationes
dc.relation.ispartofBioMed Research International, 2015, art.n.406096.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHemophilia Aes
dc.subjectRecombinant Blood Clotting Factor 8es
dc.subjectPatient with Hemophiliaes
dc.titleExperience of Preimplantation Genetic Diagnosis for Hemophilia at the University Hospital Virgen Del Rocío in Spain: Technical and Clinical Overviewes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Cirugíaes
dc.relation.projectIDPI0105-2011es
dc.relation.publisherversionhttps://www.hindawi.com/journals/bmri/2015/406096/es
dc.identifier.doi10.1155/2015/406096es
dc.journaltitleBioMed Research Internationales
dc.publication.volumen2015es
dc.publication.initialPageart.n.406096es

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