dc.creator | Fernández, Raquel María | es |
dc.creator | Peciña, Ana | es |
dc.creator | Sánchez, Beatriz | es |
dc.creator | Lozano Arana, María Dolores | es |
dc.creator | García-Lozano, Juan Carlos | es |
dc.creator | Pérez Garrido, Rosario | es |
dc.creator | Antiñolo Gil, Guillermo | es |
dc.date.accessioned | 2021-05-11T16:53:35Z | |
dc.date.available | 2021-05-11T16:53:35Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Fernández, R.M., Peciña, A., Sánchez, B., Lozano Arana, M.D., García-Lozano, J.C., Pérez Garrido, R. y Antiñolo Gil, G. (2015). Experience of Preimplantation Genetic Diagnosis for Hemophilia at the University Hospital Virgen Del Rocío in Spain: Technical and Clinical Overview. BioMed Research International, 2015, art.n.406096. | |
dc.identifier.issn | 2314-6133 | es |
dc.identifier.uri | https://hdl.handle.net/11441/108886 | |
dc.description.abstract | Hemophilia A and B are themost common hereditary hemorrhagic disorders, with an X-linked mode of inheritance. Reproductive
options for the families affectedwith hemophilia, aiming at the prevention of the birth of children with severe coagulation disorders,
include preimplantation genetic diagnosis (PGD). Here we present the results of our PGD Program applied to hemophilia, at the
Department of Genetics, Reproduction and Fetal Medicine of the University Hospital Virgen del Roc´ıo in Seville. A total of 34
couples have been included in our program since 2005 (30 for hemophilia A and 4 for hemophilia B). Overall, 60 cycles were
performed, providing a total of 508 embryos. The overall percentage of transfers per cycle was 81.7% and the live birth rate per
cycle ranged from10.3 to 24.1% depending on the methodological approach applied. Although PGD for hemophilia can be focused
on gender selection of female embryos, our results demonstrate that methodological approaches that allow the diagnosis of the
hemophilia status of every embryo have notorious advantages. Our PGD Program resulted in the birth of 12 healthy babies for
10 out of the 34 couples (29.4%), constituting a relevant achievement for the Spanish Public Health System within the field of
haematological disorders. | es |
dc.description.sponsorship | Fundacion Pública Andaluza Progreso y Salud (Consejería de Salud) of the Autonomous Government of Andalusia (PI0105-2011) | es |
dc.format | application/pdf | es |
dc.format.extent | 8 p. | es |
dc.language.iso | eng | es |
dc.publisher | Hindawi Publishing Corporation | es |
dc.relation.ispartof | BioMed Research International, 2015, art.n.406096. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Hemophilia A | es |
dc.subject | Recombinant Blood Clotting Factor 8 | es |
dc.subject | Patient with Hemophilia | es |
dc.title | Experience of Preimplantation Genetic Diagnosis for Hemophilia at the University Hospital Virgen Del Rocío in Spain: Technical and Clinical Overview | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.relation.projectID | PI0105-2011 | es |
dc.relation.publisherversion | https://www.hindawi.com/journals/bmri/2015/406096/ | es |
dc.identifier.doi | 10.1155/2015/406096 | es |
dc.journaltitle | BioMed Research International | es |
dc.publication.volumen | 2015 | es |
dc.publication.initialPage | art.n.406096 | es |