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Artículo
Engineered toxin–intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations
(Springer Nature, 2019)
Targeted killing of pathogenic bacteria without harming beneficial members of host microbiota holds promise as a strategy to cure disease and limit both antimicrobial-related dysbiosis and development of antimicrobial ...
Artículo
Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1
(National Academy of Sciences, 2011)
Yeast rad3-102, a mutant of the TFIIH complex involved in nucleotide excision repair (NER) and transcription, can perform NER initial steps but not late steps of postincision gap filing. Because removal of early-acting NER ...
Artículo
Flow Cytometry of Microencapsulated Colonies for Genetics Analysis of Filamentous Fungi
(Genetics Society of America:, 2014)
The analysis of filamentous fungi by flow cytometry has been impossible to date due to their filamentous nature and size. In this work, we have developed a method that combines single-spore microencapsulation and large-particle ...
Artículo
FACT Prevents the Accumulation of Free Histones Evicted from Transcribed Chromatin and a Subsequent Cell Cycle Delay in G1
(Public Library of Science, 2010)
The FACT complex participates in chromatin assembly and disassembly during transcription elongation. The yeast mutants affected in the SPT16 gene, which encodes one of the FACT subunits, alter the expression of G1 cyclins ...
Artículo
Role for RNA: DNA hybrids in origin-independent replication priming in a eukaryotic system
(National Academy of Sciences, 2015)
DNA replication initiates at defined replication origins along eukaryotic chromosomes, ensuring complete genome duplication within a single S-phase. A key feature of replication origins is their ability to control the onset ...
Artículo
Tubulin Folding Cofactor TBCB is a Target of the Salmonella Effector Protein SseK1
(MDPI, 2020)
Salmonella enterica serovar Typhimurium is a human and animal pathogen that uses type III secretion system effectors to manipulate the host cell and fulfill infection. SseK1 is a Salmonella effector with glycosyltransferase ...
Artículo
Identification and regulation of fusA, The polyketide synthase gene responsible for fusarin production in Fusarium fujikuroi
(American Society for Microbiology, 2012)
Fusarins are a class of mycotoxins of the polyketide family produced by different Fusarium species, including the gibberellin- producing fungus Fusarium fujikuroi. Based on sequence comparisons between polyketide synthase ...
Artículo
The CarO rhodopsin of the fungus Fusarium fujikuroi is a light-driven proton pump that retards spore germination
(Nature Publishing Group, 2015)
Rhodopsins are membrane-embedded photoreceptors found in all major taxonomic kingdoms using retinal as their chromophore. They play well-known functions in different biological systems, but their roles in fungi remain ...
Artículo
Analysis of al-2 mutations in neurospora
(Public Library of Science, 2011)
The orange pigmentation of the fungus Neurospora crassa is due to the accumulation of the xanthophyll neurosporaxanthin and precursor carotenoids. Two key reactions in the synthesis of these pigments, the formation of ...
Artículo
Chromatin reassembly factors are involved in transcriptional interference promoting HIV latency
(American Society for Microbiology, 2011)
The establishment of a stable reservoir of latently infected cells allows HIV to persist in the host. Usually, HIV infection of T cells results in integration of the viral genome, with a preference for regions in the human ...