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Mostrando ítems 211-220 de 239
Artículo
The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes
(Oxford University Press, 2020)
The ribotoxin α-sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional rRNA element within the large ribosomal subunit (60S), thereby abolishing translation. Whether ...
Artículo
Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression
(Company of Biologists Ltd, 2015)
The functions of polycomb products extend beyond their well-known activity as transcriptional regulators to include genome duplication processes. Polycomb activities during DNA replication and DNA damage repair are unclear, ...
Artículo
Formation of phenotypic lineages in Salmonella enterica by a pleiotropic fimbrial switch
(Public Library of Science, 2018)
The std locus of Salmonella enterica, an operon acquired by horizontal transfer, encodes fimbriae that permit adhesion to epithelial cells in the large intestine. Expression of the std operon is bistable, yielding a major ...
Artículo
Dispensability of the SAC depends on the time window required by aurora B to ensure chromosome biorientation
(Public Library of Science, 2015)
Aurora B and the spindle assembly checkpoint (SAC) collaborate to ensure the proper biorientation of chromosomes during mitosis. However, lack of Aurora B activity and inactivation of the SAC have a very different impact ...
Artículo
Prolonged quiescence delays somatic stem cell-like divisions in Caenorhabditis elegans and is controlled by insulin signaling
(Wiley Open Access, 2020)
Cells can enter quiescence in adverse conditions and resume proliferation when the environment becomes favorable. Prolonged quiescence comes with a cost, reducing the subsequent speed and potential to return to proliferation. ...
Artículo
Increased Aurora B activity causes continuous disruption of kinetochore-microtubule attachments and spindle instability
(National Academy of Sciences, 2014)
Aurora B kinase regulates the proper biorientation of sister chromatids during mitosis. Lack of Aurora B kinase function results in the inability to correct erroneous kinetochore-microtubule attachments and gives rise to ...
Artículo
Unravelling the genetic basis of simplex Retinitis Pigmentosa cases
(Nature Publishing Group, 2017)
Retinitis Pigmentosa (RP) is the most common form of inherited retinal dystrophy (IRD) characterized ultimately by photoreceptors degeneration. Exhibiting great clinical and genetic heterogeneity, RP can be inherited as ...
Artículo
Survey of Early-Diverging Lineages of Fungi Reveals Abundant and Diverse Mycoviruses
(American Society for Microbiology, 2020)
Mycoviruses are widespread and purportedly common throughout the fungal kingdom, although most are known from hosts in the two most recently diverged phyla, Ascomycota and Basidiomycota, together called Dikarya. To augment ...
Artículo
Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening
(Public Library of Science, 2016)
Yra1 is an essential nuclear factor of the evolutionarily conserved family of hnRNP-like export factors that when overexpressed impairs mRNA export and cell growth. To investigate further the relevance of proper Yra1 ...
Artículo
Purine homeostasis is necessary for developmental timing, germline maintenance and muscle integrity in caenorhabditis elegans
(Genetics Society of America, 2019)
Purine homeostasis is ensured through a metabolic network widely conserved from prokaryotes to humans. Purines can either be synthesized de novo, reused, or produced by interconversion of extant metabolites using the ...