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TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin
(eLife Sciences Publications, 2021)
TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor formation. TRIM37 depletion from tissue culture cells results in supernumerary foci bearing the centriolar ...
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Downregulation of Lnc-Spry1 mediates TGF-β-induced epithelial-mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms
(Springer Nature, 2017)
Long non-coding RNAs (lncRNAs) are a class of regulatory genes that participate in a wide range of biological processes, including proliferation, differentiation and development, as well as in a broad spectrum of diseases. ...
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Epigenetic Control of Salmonella enterica O-Antigen Chain Length: A Tradeoff between Virulence and Bacteriophage Resistance
(Public Library of Science, 2015)
The Salmonella enterica opvAB operon is a horizontally-acquired locus that undergoes phase variation under Dam methylation control. The OpvA and OpvB proteins form intertwining ribbons in the inner membrane. Synthesis of ...
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Bile-induced curing of the virulence plasmid in Salmonella enterica serovar typhimurium
(American Society for Microbiology, 2006)
Exposure to bile induces curing of the virulence plasmid in Salmonella enterica serovar Typhimurium (pSLT). Disruption of the ccdB gene increases pSLT curing, both spontaneous and induced by bile, suggesting that the pSLT ...
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A gene-specific requirement for FACT during transcription is related to the chromatin organization of the transcribed region
(2006)
The FACT complex stimulates transcription elongation on nucleosomal templates. In vivo experiments also involve FACT in the reassembly of nucleosomes traversed by RNA polymerase II. Since several features of chromatin ...
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Contribution of SPI-1 bistability to Salmonella enterica cooperative virulence: insights from single cell analysis
(Natural Research, 2018)
Salmonella enterica pathogenicity island 1 (SPI-1) is a gene cluster that encodes a type III secretion system and effectors involved in epithelial cell invasion. SPI-1 undergoes bistable expression, with concomitant formation ...
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A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin
(Taylor & Francis, 2021)
In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed ...
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ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection
(Public Library of Science, 2020)
During repair of DNA double-strand breaks, resection of DNA ends influences how these lesions will be repaired. If resection is activated, the break will be channeled through homologous recombination; if not, it will be ...
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Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae
(Oxford University Press, 1999)
Several mutants (spb1-spb7) have been previously identified as cold-sensitive extragenic suppressors of loss-of-function mutations in the poly(A)+-binding protein 1 of Saccharomyces cerevisiae. Cloning, sequence and ...
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Contribution of phenotypic heterogeneity to adaptive antibiotic resistance
(2014)
Antibiotic-resistant isolates of Salmonella enterica were selected on plates containing lethal concentrations of rifampicin, kanamycin, and nalidixic acid. The stability of the resistance phenotype was scored after ...