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Mostrando ítems 201-210 de 452
Artículo
Nab2 functions in the metabolism of RNA driven by polymerases II and III
(American Society for Cell Biology, 2011)
Gene expression in eukaryotes is an essential process that includes transcription, RNA processing, and export. One important player in this interface is the poly(A) + -RNA– binding protein Nab2, which ...
Artículo
The Phycomyces madA gene encodes a blue-light photoreceptor for phototropism and other light responses
(National Academy of Sciences, 2006)
Phycomyces blakesleeanus is a filamentous zygomycete fungus that produces striking elongated single cells that extend up to 10 cm into the air, with each such sporangiophore supporting a sphere containing the spores for ...
Artículo
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
(2011)
One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts ...
Artículo
The Npl3 hnRNP prevents R-loop-mediated transcription–replication conflicts and genome instability
(Cold Spring Harbor Laboratory Press, 2013)
Transcription is a major obstacle for replication fork (RF) progression and a cause of genome instability. Part of this instability is mediated by cotranscriptional R loops, which are believed to increase by suboptimal ...
Artículo
Glucose Uptake in Trichoderma harzianum: Role of gtt1
(American Society for Microbiology, 2003-08)
Using a differential display technique, the gene gtt1, which codes for a high-affinity glucose transporter, has been cloned from the mycoparasite fungus Trichoderma harzianum CECT 2413. The deduced protein sequence of the ...
Artículo
Rpd3l contributes to the DNA damage sensitivity of saccharomyces cerevisiae checkpoint mutants
(Genetics Society of America, 2019)
DNA replication forks that are stalled by DNA damage activate an S-phase checkpoint that prevents irreversible fork arrest and cell death. The increased cell death caused by DNA damage in budding yeast cells lacking the ...
Artículo
Salmonella type III secretion effector SlrP is an E3 ubiquitin ligase for mammalian thioredoxin
(Elsevier, 2009)
Salmonella enterica encodes two virulence-related type III secretion systems in Salmonella pathogenicity islands 1 and 2, respectively. These systems mediate the translocation of protein effectors into the eukaryotic host ...
Artículo
A Carotenogenic Enzyme Aggregate in Phycomyces: Evidence from Quantitive Complementation
(National Academy of Sciences, 1971)
Wild-type Phycomyces blakesleeanus accumulates β-carotene, while the mutant strain C2 is unable to synthesize carotenoids, and the mutant strain C9 accumulates lycopene. Heterokaryons containing a proportion, p, of C2 ...
Artículo
Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast
(Frontiers Media, 2014)
The 5′ to 3′ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has ...
Artículo
An automated method for the analysis of food intake behaviour in Caenorhabditis elegans
(Nature Publishing Group, 2018)
The study of mechanisms that govern feeding behaviour and its related disorders is a matter of global health interest. The roundworm Caenorhabditis elegans is becoming a model organism of choice to study these conserved ...