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Tesis Doctoral
Artículo
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Host cell type-dependent translocation and PhoP-mediated positive regulation of the effector SseK1 of Salmonella enterica.
(Frontiers Media S. A., 2015)
Salmonella enterica expresses two virulence-related type III secretion systems (T3SSs) encoded in Salmonella pathogenicity island 1 (SPI1) and SPI2, respectively. SseK1 is a poorly characterized substrate of the SPI2-encoded ...
Artículo
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Salmonella Type III Secretion Effector SrfJ: A Glucosylceramidase Affecting the Lipidome and the Transcriptome of Mammalian Host Cells
(MDPI, 2023)
Type III secretion systems are found in many Gram-negative pathogens and symbionts of animals and plants. Salmonella enterica has two type III secretion systems associated with virulence, one involved in the invasion of ...
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Human prefoldin modulates co-transcriptional pre-mRNA splicing
(Oxford University Press, 2021)
Prefoldin is a heterohexameric complex conserved from archaea to humans that plays a cochaperone role during the co-translational folding of actin and tubulin monomers. Additional functions of prefoldin have been described, ...
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The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes
(Oxford University Press, 2020)
The ribotoxin α-sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional rRNA element within the large ribosomal subunit (60S), thereby abolishing translation. Whether ...
Artículo
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Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression
(Company of Biologists Ltd, 2015)
The functions of polycomb products extend beyond their well-known activity as transcriptional regulators to include genome duplication processes. Polycomb activities during DNA replication and DNA damage repair are unclear, ...
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Formation of phenotypic lineages in Salmonella enterica by a pleiotropic fimbrial switch
(Public Library of Science, 2018)
The std locus of Salmonella enterica, an operon acquired by horizontal transfer, encodes fimbriae that permit adhesion to epithelial cells in the large intestine. Expression of the std operon is bistable, yielding a major ...
Artículo
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Dispensability of the SAC depends on the time window required by aurora B to ensure chromosome biorientation
(Public Library of Science, 2015)
Aurora B and the spindle assembly checkpoint (SAC) collaborate to ensure the proper biorientation of chromosomes during mitosis. However, lack of Aurora B activity and inactivation of the SAC have a very different impact ...
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Prolonged quiescence delays somatic stem cell-like divisions in Caenorhabditis elegans and is controlled by insulin signaling
(Wiley Open Access, 2020)
Cells can enter quiescence in adverse conditions and resume proliferation when the environment becomes favorable. Prolonged quiescence comes with a cost, reducing the subsequent speed and potential to return to proliferation. ...
Tesis Doctoral
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Design of biological sensors based on the OpvAB phase variation system of Salmonella enterica
(2020-02-21)
Este trabajo se ha basado en investigaciones previas de nuestro grupo sobre el operón opvAB de Salmonella enterica y ha utilizado dichos conocimientos para diseñar y desarrollar tres aplicaciones biotecnológicas: (i) la ...