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Mostrando ítems 1-6 de 6
Artículo
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors
(American Society for Clinical Investigation, 2022)
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the ...
Artículo
Ceramide chain length–dependent protein sorting into selective endoplasmic reticulum exit sites
(American Association for the Advancement of Science, 2020)
Protein sorting in the secretory pathway is crucial to maintain cellular compartmentalization and homeostasis. In addition to coat-mediated sorting, the role of lipids in driving protein sorting during secretory transport ...
Artículo
Determination of the lipid composition of the GPI anchor
(PLOS, 2021)
In eukaryotic cells, a subset of cell surface proteins is attached by the glycolipid glycosylphosphatidylinositol (GPI) to the external leaflet of the plasma membrane where they play important roles as enzymes, receptors, ...
Artículo
CD4+ and CD8+ T-cell responses in bone marrow to fatty acids in high-fat diets
(Elsevier, 2022)
Obesity is associated with disruptions in the adaptive immune system; however, dietary fatty acids in high-fat diets (HFDs) that induce obesity have consequences that are currently unclear regarding T-cell maintenance in ...
Artículo
DC electrical stimulation enhances proliferation and differentiation on N2a and MC3T3 cell lines
(Springer Nature, 2022)
Background: Electrical stimulation is a novel tool to promote the differentiation and proliferation of precursor cells. In this work we have studied the effects of direct current (DC) electrical stimulation on neuroblastoma ...
Artículo
Quality-controlled ceramide-based GPI-anchored protein sorting into selective ER exit sites
(Elsevier, 2022)
Glycosylphosphatidylinositol-anchored proteins (GPI-APs) exit the endoplasmic reticulum (ER) through a specialized export pathway in the yeast Saccharomyces cerevisiae. We have recently shown that a very-long acyl chain ...