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Artículo
An approach to prospective primary school teachers' concept of environment and biodiversity through their design of educational itineraries: Validation of an evaluation rubric
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
The aim of this work is to promote outdoor activities to bring students closer to the environment and the biodiversity of their surroundings. In this sense, educational itineraries are a very good educational resource that ...
Artículo
A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity
(Springer Nature, 2020)
Artículo
CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
(Springer Nature, 2021)
Proper chromosome segregation is essential to avoid aneuploidy, yet this process fails with increasing age in mammalian oocytes. Here we report a role for the scarcely described protein CENP-V in oocyte spindle formation ...
Artículo
Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
(Springer Nature, 2021)
The human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis is started near Aß plaques in ...
Artículo
EpiGraph: an open-source platform to quantify epithelial organization
(Oxford University Press, 2020)
Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational geometry and graph theory to measure the degree of order of any packed tissue. EpiGraph goes beyond ...
Artículo
An opinion on the regulation of bone marrow adipose tissue by dietary fatty acids
(CSIC, 2020)
Obesity has a significant impact on predisposition to various diseases and also affects the viability and choice of haematopoietic stem cells (HSCs) to favour myeloid cell production and/or turnover, all of which are ...
Artículo
Ceramide chain length–dependent protein sorting into selective endoplasmic reticulum exit sites
(American Association for the Advancement of Science, 2020)
Protein sorting in the secretory pathway is crucial to maintain cellular compartmentalization and homeostasis. In addition to coat-mediated sorting, the role of lipids in driving protein sorting during secretory transport ...
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Determination of the lipid composition of the GPI anchor
(PLOS, 2021)
In eukaryotic cells, a subset of cell surface proteins is attached by the glycolipid glycosylphosphatidylinositol (GPI) to the external leaflet of the plasma membrane where they play important roles as enzymes, receptors, ...
Artículo
A Role for Lipids in Protein Sorting?
(Swiss Chemical Society, 2021)
Lipid and protein diversity provides structural and functional identity to the membrane compartments that define the eukaryotic cell. This compositional heterogeneity is maintained by the secretory pathway, which feeds ...
Artículo
Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old
(Wiley, 2021)
Older patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. We sought the distinctive characteristics of DILI in older patients across age groups. A total of 882 ...