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Mostrando ítems 1-10 de 29
Artículo
EpiGraph: an open-source platform to quantify epithelial organization
(Oxford University Press, 2020)
Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational geometry and graph theory to measure the degree of order of any packed tissue. EpiGraph goes beyond ...
Artículo
Mechanics and self-organization in tissue development
(Elsevier, 2021)
Self-organization is an all-important feature of living systems that provides the means to achieve specialization and functionality at distinct spatio-temporal scales. Herein, we review this concept by addressing the packing ...
Artículo
The complex three-dimensional organization of epithelial tissues
(The Company of Biologists Ltd., 2021)
Understanding the cellular organization of tissues is key to developmental biology. In order to deal with this complex problem, researchers have taken advantage of reductionist approaches to reveal fundamental morphogenetic ...
Artículo
Epithelial organisation revealed by a network of cellular contacts
(Nature Publishing Group, 2011)
The emergence of differences in the arrangement of cells is the first step towards the establishment of many organs. Understanding this process is limited by the lack of systematic characterization of epithelial organisation. ...
Artículo
Neuromuscular disease classification system
(Spie-soc photo-optical instrumentation engineers, 2013)
Diagnosis of neuromuscular diseases is based on subjective visual assessment of biopsies from patients by the pathologist specialist. A system for objective analysis and classification of muscular dystrophies and ...
Artículo
CartoCell, a high-content pipeline for 3D image analysis, unveils cell morphology patterns in epithelia
(Elsevier, 2023)
Decades of research have not yet fully explained the mechanisms of epithelial self-organization and 3D packing. Single-cell analysis of large 3D epithelial libraries is crucial for understanding the assembly and function ...
Artículo
Age-mediated transcriptomic changes in adult mouse substantia nigra
(2013)
Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson’s disease (PD). Until now, molecular mechanisms behind SNpc aging have not been fully investigated using ...
Artículo
X-ray emission from a liquid curtain jet when irradiated by femtosecond laser pulses
(Springer Nature, 2017)
Laser-based sources of ionizing radiation have attracted considerable attention in the last years for their broad potential applications. However, the stability and robustness of such sources are still issues that need to ...
Artículo
Live imaging of Drosophila imaginal disc development
(National Academy of Sciences, 2010)
Live imaging has revolutionized the analysis of developmental biology over the last few years. The ability to track in real time the dynamic processes that occur at tissue and cellular levels gives a much clearer view of ...