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Artículo
ATM specifically mediates repair of double-strand breaks with blocked DNA ends
(Nature Publishing Group, 2014)
Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator ...
Artículo
Topological Progression in Proliferating Epithelia Is Driven by a Unique Variation in Polygon Distribution
(Public Library of Science, 2013)
Morphogenesis is consequence of lots of small coordinated variations that occur during development. In proliferating stages, tissue growth is coupled to changes in shape and organization. A number of studies have analyzed ...
Artículo
Rules of tissue packing involving different cell types: human muscle organization
(Nature Publishing Group, 2017)
Natural packed tissues are assembled as tessellations of polygonal cells. These include skeletal muscles and epithelial sheets. Skeletal muscles appear as a mosaic composed of two different types of cells: the “slow” and ...
Artículo
Fundamental physical cellular constraints drive self-organization of tissues
(Wiley-Blackwell, 2016)
Morphogenesis is driven by small cell shape changes that modulate tissue organization. Apical surfaces of proliferating epithelial sheets have been particularly well studied. Currently, it is accepted that a stereotyped ...
Tesis Doctoral