Artículo
Biocompatibility and Cellular Behavior of TiNbTa Alloy with Adapted Rigidity for the Replacement of Bone Tissue
Autor/es | Giner García, Mercedes
Chicardi Augusto, Ernesto Costa Martins, Alzenira de Fátima Santana, Laura Vázquez Gámez, María de los Ángeles García Garrido, Cristina Colmenero, Miguel Ángel Olmo-Montes, Francisco Jesús Torres Hernández, Yadir Montoya García, María José |
Departamento | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2021-01 |
Fecha de depósito | 2021-01-27 |
Publicado en |
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Resumen | In this work, the mechanical and bio-functional behavior of a TiNbTa alloy is evaluated as a potential prosthetic biomaterial used for cortical bone replacement. The results are compared with the reference Ti c.p. used as ... In this work, the mechanical and bio-functional behavior of a TiNbTa alloy is evaluated as a potential prosthetic biomaterial used for cortical bone replacement. The results are compared with the reference Ti c.p. used as biomaterials for bone-replacement implants. The estimated mechanical behavior for TiNbTa foams was also compared with the experimental Ti c.p. foams fabricated by the authors in previous studies. A TiNbTa alloy with a 20–30% porosity could be a candidate for the replacement of cortical bone, while levels of 80% would allow the manufacture of implants for the replacement of trabecular bone tissue. Regarding biocompatibility, in vitro TiNbTa, cellular responses (osteoblast adhesion and proliferation) were compared with cell growth in Ti c.p. samples. Cell adhesion (presence of filopodia) and propagation were promoted. The TiNbTa samples had a bioactive response similar to that of Ti c.p. However, TiNbTa samples show a better balance of bio-functional behavior (promoting osseointegration) and biomechanical behavior (solving the stress-shielding phenomenon and guaranteeing mechanical resistance). |
Identificador del proyecto | PID2019-109371GB-I00
US-1259771 |
Cita | Giner García, M., Chicardi Augusto, E., Costa Martins, A.d.F., Santana, L., Vázquez Gámez, M.d.l.Á., García Garrido, C.,...,Montoya García, M.J. (2121). Biocompatibility and Cellular Behavior of TiNbTa Alloy with Adapted Rigidity for the Replacement of Bone Tissue. Metals, 11 (1), 130-. |
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