dc.creator | Rodríguez Mateo, Cristina | es |
dc.creator | Torres, Belén | es |
dc.creator | Gutiérrez Pozo, Gabriel | es |
dc.creator | Pintor Toro, José Antonio | es |
dc.date.accessioned | 2020-10-30T17:11:27Z | |
dc.date.available | 2020-10-30T17:11:27Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Rodríguez Mateo, C., Torres, B., Gutiérrez Pozo, G. y Pintor Toro, J.A. (2017). Downregulation of Lnc-Spry1 mediates TGF-β-induced epithelial-mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms. Cell Death and Differentiation, 24, 785-797. | |
dc.identifier.issn | 1350-9047 | es |
dc.identifier.issn | 1476-5403 | es |
dc.identifier.uri | https://hdl.handle.net/11441/102397 | |
dc.description.abstract | Long non-coding RNAs (lncRNAs) are a class of regulatory genes that participate in a wide range of biological processes, including proliferation, differentiation and development, as well as in a broad spectrum of diseases. Although the role of lncRNAs in TGF-β-induced epithelial-to-mesenchymal transition (EMT) has been well established, little is known about the role of lncRNAs as immediate-early regulators of EMT. Here lnc-Spry1 is identified as an immediate-early regulator of EMT that is downregulated by TGF-β. It is also found that knockdown of lnc-Spry1 promotes a mesenchymal-like phenotype and results in increased cell migration and invasion. In addition, it is shown that lnc-Spry1 depletion preferentially affects the expression of TGF-β-regulated gene targets. Moreover, lnc-Spry1 associates with U2AF65 splicing factor, suggesting a role in alternative splicing. Depletion of lnc-Spry1 induces, as TGF-β, isoform switching of fibroblast growth factor receptors, resulting in FGF-2-sensitive cells. Taken together, these results show that lnc-Spry1 could act as an early mediator of TGF-β signaling and reveal different roles for a lncRNA in modulating transcriptional and posttranscriptional gene expression. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad SAF2014-57632-P | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer Nature | es |
dc.relation.ispartof | Cell Death and Differentiation, 24, 785-797. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Downregulation of Lnc-Spry1 mediates TGF-β-induced epithelial-mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.projectID | SAF2014-57632-P | es |
dc.relation.publisherversion | http://dx.doi.org/10.1038/cdd.2017.9 | es |
dc.identifier.doi | 10.1038/cdd.2017.9 | es |
dc.journaltitle | Cell Death and Differentiation | es |
dc.publication.volumen | 24 | es |
dc.publication.initialPage | 785 | es |
dc.publication.endPage | 797 | es |