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Artículo
Integrating Comorbidities and Phenotype-Based Medicine in Patient-Centered Medicine in COPD
dc.creator | López-Campos Bodineau, José Luis | es |
dc.creator | Ruiz Duque, Borja | es |
dc.creator | Carrasco Hernández, Laura | es |
dc.creator | Caballero Eraso, Candelaria | es |
dc.date.accessioned | 2020-09-16T13:23:06Z | |
dc.date.available | 2020-09-16T13:23:06Z | |
dc.date.issued | 2020-08-25 | |
dc.identifier.citation | López Campos, J.L., Ruiz Duque, B., Carrasco Hernández, L. y Caballero Eraso, C. (2020). Integrating Comorbidities and Phenotype-Based Medicine in Patient-Centered Medicine in COPD. Journal of Clinical Medicine, 9 (2745), 1-15. | |
dc.identifier.issn | 2077-0383 | es |
dc.identifier.uri | https://hdl.handle.net/11441/101213 | |
dc.description.abstract | Despite recent notable innovations in the management of chronic obstructive pulmonary disease (COPD), no major advances in patient-centered medicine have been achieved. Current guidelines base their proposals on the average results from clinical trials, leading to what could be termed ‘means-based’ medical practice. However, the therapeutic response is variable at the patient level. Additionally, the variability of the clinical presentation interacts with comorbidities to form a complex clinical scenario for clinicians to deal with. Consequently, no consensus has been reached over a practical approach for combining comorbidities and disease presentation markers in the therapeutic algorithm. In this context, from the patients’ first visit, the clinician faces four major dilemmas: (1) establishing the correct diagnosis of COPD as opposed to other airway diseases, such as bronchial asthma; (2) deciding on the initial therapeutic approach based on the clinical characteristics of each case; (3) setting up a study strategy for non-responding patients; (4) pursuing a follow-up strategy with two well-defined periods according to whether close or long-term follow-up is required. Here, we will address these major dilemmas in the search for a patient-centered approach to COPD management and suggest how to combine them all in a single easy-to-use strategy. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | doi:10.3390/jcm9092745 | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | COPD | es |
dc.subject | Clinical phenotypes | es |
dc.subject | Comorbidities | es |
dc.subject | Personalized medicine | es |
dc.title | Integrating Comorbidities and Phenotype-Based Medicine in Patient-Centered Medicine in COPD | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.journaltitle | Journal of Clinical Medicine | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 2745 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 15 | es |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Integrating.pdf | 1.194Mb | ![]() | Ver/ | |