Artículo
Limited value of single sampling for IgM antibody determination as a diagnostic approach for acute hepatitis E virus infection
Autor/es | Rivero-Juárez, Antonio
López-López, Pedro Pineda Vergara, Juan Antonio Alados, Juan Carlos Fuentes-López, Ana Ramírez-Arellano, Encarnación Freyre Carrillo, Carolina Rivero, Antonio |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2021-07-07 |
Fecha de depósito | 2022-12-07 |
Publicado en |
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Resumen | ABSTRACT The objective was to evaluate the accuracy of a single determination of IgM
antibodies for hepatitis E virus (HEV) diagnosis in patients with acute hepatitis. A prospec tive study included patients with suspicion ... ABSTRACT The objective was to evaluate the accuracy of a single determination of IgM antibodies for hepatitis E virus (HEV) diagnosis in patients with acute hepatitis. A prospec tive study included patients with suspicion of HEV infection, defined as individuals with acute hepatitis showing negative results for serological and molecular markers of other hep atitis viruses. All patients were evaluated for hepatitis E virus infection, including both IgM antibodies and viral RNA determinations. Hepatitis E virus infection was defined as positivity for any of these markers. A total of 182 patients were included in the study, of whom 68 (37.4%) were diagnosed with HEV infection. Of these, 29 (42.6%) were positive for both IgM and HEV RNA, 25 (36.8%) were positive only for IgM antibodies, and 14 (20.6%) were posi tive only for HEV RNA. Considering only those individuals who were positive for IgM anti bodies, 54 of the 68 total cases (79.4%) could be identified, showing a percentage of false negative individuals of 20.6%. The diagnostic algorithm of hepatitis E virus infection in patients with acute hepatitis should include the determination of both IgM antibodies and HEV RNA because single sampling for IgM antibody determination led to an important pro portion of misdiagnosed cases. |
Cita | Rivero-Juárez, A., López-López, P., Pineda Vergara, J.A., Alados, J.C., Fuentes-López, A., Ramírez-Arellano, E.,...,Rivero, A. (2021). Limited value of single sampling for IgM antibody determination as a diagnostic approach for acute hepatitis E virus infection. Microbiology Spectrum, 9 (1), e00382-21. https://doi.org/10.1128/Spectrum.00382-21. |
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