Artículo
Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response
Autor/es | Perez-Gomez, Alberto
Gasca-Capote, Carmen Vitalle, Joana Ostos Marcos, Francisco José Serna Gallego, Ana Trujillo-Rodriguez, María Rafii-El-Idrissi Benhnia, Mohammed Ruiz Mateos, Ezequiel |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-10-28 |
Publicado en |
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Resumen | SARS-CoV-2 specific T-cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the ... SARS-CoV-2 specific T-cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS-CoV-2 specific T-cell response with antibody levels in these three scenarios is needed. In the present study, we found that, in acute infection, while mild disease was associated with high T-cell polyfunctionality biased to IL-2 production and inversely correlated with anti-S IgG levels, combinations only including IFN-γ with the absence of perforin production predominated in severe disease. Seven months after infection, both non-hospitalised and previously hospitalised patients presented robust anti-S IgG levels and SARS-CoV-2 specific T-cell response. In addition, only previously hospitalised patients showed a T-cell exhaustion profile. Finally, combinations including IL-2 in response to S protein of endemic coronaviruses were the ones associated with SARS-CoV-2 S-specific T-cell response in pre-COVID-19 healthy donors’ samples. These results could have implications for protective immunity against SARS-CoV-2 and recurrent COVID-19 and may help for the design of new prototypes and boosting vaccine strategies. |
Agencias financiadoras | Instituto de Salud Carlos III European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Consejería de Salud, Junta de Andalucía Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades, Junta de Andalucia |
Identificador del proyecto | RH-0037-2020
PI19/01127 |
Cita | Perez-Gomez, A., Gasca-Capote, C., Vitalle, J., Ostos Marcos, F.J., Serna Gallego, A., Trujillo-Rodriguez, M.,...,Ruiz Mateos, E. (2022). Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response. Clinical and translational medicine, 12 (4), e802. https://doi.org/10.1002/ctm2.802. |
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