dc.creator | Perez-Gomez, Alberto | es |
dc.creator | Gasca-Capote, Carmen | es |
dc.creator | Vitalle, Joana | es |
dc.creator | Ostos Marcos, Francisco José | es |
dc.creator | Serna Gallego, Ana | es |
dc.creator | Trujillo-Rodriguez, María | es |
dc.creator | Rafii-El-Idrissi Benhnia, Mohammed | es |
dc.creator | Ruiz Mateos, Ezequiel | es |
dc.date.accessioned | 2022-10-28T16:04:30Z | |
dc.date.available | 2022-10-28T16:04:30Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Perez-Gomez, A., Gasca-Capote, C., Vitalle, J., Ostos Marcos, F.J., Serna Gallego, A., Trujillo-Rodriguez, M.,...,Ruiz Mateos, E. (2022). Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response. Clinical and translational medicine, 12 (4), e802. https://doi.org/10.1002/ctm2.802. | |
dc.identifier.issn | 2001-1326 | es |
dc.identifier.uri | https://hdl.handle.net/11441/138485 | |
dc.description.abstract | SARS-CoV-2 specific T-cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS-CoV-2 specific T-cell response with antibody levels in these three scenarios is needed. In the present study, we found that, in acute infection, while mild disease was associated with high T-cell polyfunctionality biased to IL-2 production and inversely correlated with anti-S IgG levels, combinations only including IFN-γ with the absence of perforin production predominated in severe disease. Seven months after infection, both non-hospitalised and previously hospitalised patients presented robust anti-S IgG levels and SARS-CoV-2 specific T-cell response. In addition, only previously hospitalised patients showed a T-cell exhaustion profile. Finally, combinations including IL-2 in response to S protein of endemic coronaviruses were the ones associated with SARS-CoV-2 S-specific T-cell response in pre-COVID-19 healthy donors’ samples. These results could have implications for protective immunity against SARS-CoV-2 and recurrent COVID-19 and may help for the design of new prototypes and boosting vaccine strategies. | es |
dc.format | application/pdf | es |
dc.format.extent | 21 p. | es |
dc.language.iso | eng | es |
dc.publisher | WILEY | es |
dc.relation.ispartof | Clinical and translational medicine, 12 (4), e802. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | COVID-19 | es |
dc.subject | Endemic coronaviruses | es |
dc.subject | IL-2 | es |
dc.subject | Nucleocapsid | es |
dc.subject | Polyfunctionality | es |
dc.subject | SARS-CoV-2 | es |
dc.subject | Spike | es |
dc.subject | T-cell response | es |
dc.title | Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.projectID | RH-0037-2020 | es |
dc.relation.projectID | PI19/01127 | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/ctm2.802 | es |
dc.identifier.doi | 10.1002/ctm2.802 | es |
dc.journaltitle | Clinical and translational medicine | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | e802 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Consejería de Salud, Junta de Andalucía | es |
dc.contributor.funder | Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades, Junta de Andalucia | es |