Artículo
Quantitative Analysis of Somatostatin and Dopamine Receptors Gene Expression Levels in Non-Functioning Pituitary Tumors and Association with Clinical and Molecular Aggressiveness Features
Autor/es | Flores Martínez, Álvaro
Venegas Moreno, Eva Dios, Elena Remón-Ruiz, Pablo Gros-Herguido, Noelia Vázquez Borrego, Mari C. Soto Moreno, Alfonso Manuel |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2020-09-22 |
Fecha de depósito | 2020-11-26 |
Publicado en |
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Resumen | The primary treatment for non-functioning pituitary tumors (NFPTs) is surgery,
but it is often unsuccessful. Previous studies have reported that NFPTs express receptors for
somatostatin (SST1-5) and dopamine (DRDs) ... The primary treatment for non-functioning pituitary tumors (NFPTs) is surgery, but it is often unsuccessful. Previous studies have reported that NFPTs express receptors for somatostatin (SST1-5) and dopamine (DRDs) providing a rationale for the use of dopamine agonists and somatostatin analogues. Here, we systematically assessed SST1-5 and DRDs expression by real-time quantitative PCR (RT-qPCR) in a large group of patients with NFPTs (n = 113) and analyzed their potential association with clinical and molecular aggressiveness features. SST1-5 expression was also evaluated by immunohistochemistry. SST3 was the predominant SST subtype detected, followed by SST2, SST5, and SST1. DRD2 was the dominant DRD subtype, followed by DRD4, DRD5, and DRD1. A substantial proportion of NFPTs displayed marked expression of SST2 and SST5. No major association between SSTs and DRDs expression and clinical and molecular aggressiveness features was observed in NFPTs |
Identificador del proyecto | PI16/00175
PI16/00264 A-0006-2017 A-0055-2018 C-0015-2014 RC-0006-2018 BFU2016-80360-R PID2019-105564RB-I00 BIO-0139 |
Cita | Flores Martínez, Á., Venegas Moreno, E., Dios, E., Remón-Ruiz, P., Gros-Herguido, N., Vázquez Borrego, M.C. y Soto Moreno, A.M. (2020). Quantitative Analysis of Somatostatin and Dopamine Receptors Gene Expression Levels in Non-Functioning Pituitary Tumors and Association with Clinical and Molecular Aggressiveness Features. Journal of Clinical Medicine, 9 (9) |
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