Artículo
Temporal expression patterns of the melatoninergic system in the human thymus of children
Autor/es | Cruz-Chamorro, Ivan
Álvarez-Sánchez, Nuria Escalante-Andicoechea, Cristina Carrillo Vico, Antonio Rubio, Amalia Guerrero, Juan Miguel Molinero, Patrocinio Lardone, Patricia Judith |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2019 |
Fecha de depósito | 2020-10-26 |
Publicado en |
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Premios | Premio Anual Publicación Científica Destacada de la US. Facultad de Medicina Premio Mensual Publicación Científica Destacada de la US. Facultad de Medicina |
Resumen | Objectives: To obtain greater knowledge of the extra-pineal sources of melatonin during development, the amount of indolamine and the
expression levels of the last two enzymes involved in its biosynthesis, Arylalkylamine ... Objectives: To obtain greater knowledge of the extra-pineal sources of melatonin during development, the amount of indolamine and the expression levels of the last two enzymes involved in its biosynthesis, Arylalkylamine N-acetyltransferase (AANAT) and acetylserotonin Omethyltransferase (ASMT), were analyzed in the human thymus from children from three different age groups (from days to years). The melatonin membrane and nuclear receptor expression levels also were studied. Methods: Quantitative reverse transcriptase PCR and western blot were performed to investigate the receptor and enzyme expression levels. The results were examined and correlated with the ages of the thymuses. Results: We found high levels of indolamine in the thymuses of newborns (younger than 1 month), which decreased during development; thymuses from the months (from 2 to 11 months) and years (from 1 to 12 years) groups showed lower levels. A similar decline was also observed in the mRNA of the AANAT enzyme and the expression levels of melatonin receptors. However, ASMT expression was exactly the opposite, with low levels in the newborn group and higher levels in the years group. Our results show that the thymic synthesis of melatonin occurs very early in childhood. Additionally, this is the first report that is focused on melatonin receptors expression in the human thymus. Conclusion: Considering the limited melatonin synthesis performed by the newborn pineal gland, we suggest that the high levels of melatonin found in human thymus in this experimental group arise from synthesis in the tissue itself, which could be contributing to the immune efficiency at the thymic level. |
Identificador del proyecto | PI-0209-2010
CTS160 PI-0485-2014 FPU13/01210 RD06/ 0013/0001 RD12/0043/0012 |
Cita | Cruz-Chamorro, I., Álvarez-Sánchez, N., Escalante-Andicoechea, C., Carrillo Vico, A., Rubio, A., Guerrero, J.M.,...,Lardone, P.J. (2019). Temporal expression patterns of the melatoninergic system in the human thymus of children. Molecular Metabolism, 28. https://doi.org/10.1016/j.molmet.2019.07.007. |
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1-s2.0-S221287781930585X-main.pdf | 1.103Mb | [PDF] | Ver/ | Temporal expression |