Browsing by Author "Cruz Merino, Luis de la"
Now showing items 1-20 of 30
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Article
5-year outcomes with cobimetinib plus vemurafenib in BRAFV600 mutation⇓positive advanced melanoma: extended follow-up of the coBRIM study
(American Association for Cancer Research, 2021)Purpose: The randomized phase III coBRIM study (NCT01689519) demonstrated improved progression-free survival (PFS) and ...
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Article
Adjuvant nivolumab for stage III/IV melanoma: evaluation of safety outcomes and association with recurrence-free survival
(BMJ Publishing Group, 2021-08-21)Background Several therapeutic options are now available in the adjuvant melanoma setting, mandating an understanding ...
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PhD Thesis
Análisis del perfil de respuesta inmune en sangre periférica inducido por tratamiento sistémico en el carcinoma de mama avanzado
(2021-06-09)La identificación de los diferentes elementos que intervienen en el proceso de inmunoedición, parece clave para explicar ...
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PhD Thesis
Caracterización del perfil inmunitario en sangre periférica y en tejido de carcinoma de mama con tratamiento neoadyuvante. Estudio de su potencial papel pronóstico y predictivo de respuesta
(2020-01-16)Introducción: Los estudios traslacionales permiten una correcta interrelación entre la investigación básica y la clínica. ...
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Article
Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
(Nature Publishing Group, 2021-07-13)Identification of the different elements intervening at the tumor microenvironment seems key to explain clinical evolution ...
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Article
Circulating myeloid-derived suppressor cells and regulatory T cells as immunological biomarkers in refractory/relapsed diffuse large B-cell lymphoma: translational results from the R2-GDP-GOTEL trial
(BMJ, 2021)Background The search for immunological markers with ability of predicting clinical outcome is a priority in lymphomas, ...
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PhD Thesis
Estudio poblaciones celulares en pacientes con linfoma difuso de células B grandes refractarios o en recaída: papel de las células supresoras de origen mieloide en respuesta al tratamiento R2-GDP
(2020-07-13)La inmunoedición, que se caracteriza por el escape que realizan las células malignas de la inmunovigilancia antitumoral, ...
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Article
Ewing Sarcoma Meets Epigenetics, Immunology and Nanomedicine: Moving Forward into Novel Therapeutic Strategies
(MDPI, 2022-11-07)Ewing Sarcoma (EWS) is an aggressive bone and soft tissue tumor that mainly affects children, adolescents, and young adults. ...
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Article
Genes involved in immune reinduction may constitute biomarkers of response for metastatic melanoma patients treated with targeted therapy
(MDPI, 2022)Targeted therapy in metastatic melanoma often achieves a major tumour regression response and significant long-term survival ...
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PhD Thesis
Immune Biomarkers In Peripheral Blood In Patients With HER2 Negative Advanced Breast Cancer Treated With A Chemoimmunotherapy Schedule Based On Pembrolizumab And Gemcitabine. – Translational Substudy Of The PANGEA- Breast Cancer Trial (GEICAM/2015-04)
(2022-03-31)Within the last years, immune checkpoint inhibitors (ICI) have constituted a major breakthrough in cancer research. These ...
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Article
Immunometabolism modulation in therapy
(MDPI, 2021-07-09)The study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the ...
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Article
Intermittent BRAF inhibition in advanced BRAF mutated melanoma results of a phase II randomized trial
(Nature Research, 2021-12-01)Combination treatment with BRAF (BRAFi) plus MEK inhibitors (MEKi) has demonstrated survival benefit in patients with ...
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Article
Lenalidomide plus R-GDP (R2-GDP) in Relapsed/ Refractory Diffuse Large B-Cell Lymphoma: Final Results of the R2-GDP-GOTEL Trial and Immune Biomarker Subanalysis
(AMER ASSOC CANCER RESEARCH, 2022)Purpose: New therapeutic options are needed in relapsed/refrac tory diffuse large B-cell lymphoma (R/R DLBCL). Lenalidomide ...
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Article
Leptin, both bad and good actor in cancer
(MDPI, 2021)Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in obesity. Leptin exerts many ...
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Article
Long-term complete response to intrathecal trastuzumab in a patient with leptomeningeal carcinomatosis due to her2- overexpressing breast cancer: Case report
(Lippincott Williams & Wilkins, 2020-01)Introduction: Leptomeningeal dissemination due to HER2-overexpressing breast cancer is a rare and hard to treat ...
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Article
Low levels of granulocytic myeloid-derived suppressor cells may be a good marker of survival in the follow-up of patients with severe COVID-19
(Frontiers Media S.A., 2022)Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a disease (coronavirus disease 2019, ...
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Article
Lower Survival and Increased Circulating Suppressor Cells in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma with Deficit of Vitamin D Levels Using R-GDP Plus Lenalidomide (R2-GDP): Results from the R2-GDP-GOTEL Trial
(MDPI, 2021-09-15)The search of prognostic factors is a priority in diffuse large B-cell lymphoma (DLBCL) due to its aggressiveness. We ...
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Article
Metabolic classification and intervention opportunities for tumor energy dysfunction
(MDPI, 2021)A comprehensive view of cell metabolism provides a new vision of cancer, conceptualized as tissue with cellular-altered ...
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Article
New insights into the role of the immune microenvironment in breast carcinoma
(2013)Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast ...
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Article
Obesity and Breast Cancer: Role of Leptin
(2019-07-18)Obesity-related breast cancer is an important threat that affects especially post-menopausal women. The link between ...