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Listar por autor "Pernia Leal, Manuel"
Mostrando ítems 1-20 de 21
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Artículo
Bi-Magnetic Core-Shell CoFe2O4@MnFe2O4 Nanoparticles for In Vivo Theranostics
Nica, Valentín; Caro Salazar, Carlos; Páez-Muñoz, José María; Pernia Leal, Manuel; García-Martín, María Luisa (MDPI, 2020)In this work, we report the synthesis and characterization of three magnetic nanosystems, CoFe2O4, CoFe2O4@ZnFe2O4, and ...
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Artículo
Biological Evaluation of Carbohydrate-based Aprepitant Analogs for Neuroblastoma Treatment
Valdivia Giménez, Victoria Esther; Recio Jiménez, Rocío; Lerena, Patricia; Pozo, Esther; Serrano, Rosario; Calero, Raúl; Pintado, Cristina; Pernia Leal, Manuel; Moreno Rodríguez, Nazaret; Organero, Juan Ángel; Khiar, Noureddine; Fernández Fernández, Inmaculada (Elsevier, 2024)Different studies using Aprepitant, a NK1R antagonist currently used as a clinical drug for treating chemotherapy-related ...
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Artículo
Biologically Relevant Micellar Nanocarrier Systems for Drug Encapsulation and Functionalization of Metallic Nanoparticles
Valdivia Giménez, Victoria Esther; Gimeno Ferrero, Raúl; Pernia Leal, Manuel; Paggiaro, Chiara; Fernández Romero, Ana María; González Rodríguez, María Luisa; Fernández Fernández, Inmaculada (MDPI, 2022)The preparation of new and functional nanostructures has received more attention in the scientific community in the past ...
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Artículo
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity
Recio Jiménez, Rocío; Lerena Pérez, Patricia; Pozo Torres, Esther; Calderón Montaño, José Manuel; Burgos Morón, Estefanía; López Lázaro, Miguel; Valdivia Giménez, Victoria Esther; Pernia Leal, Manuel; Mouillac, Bernard; Organero, Juan Ángel; Khiar, Noureddine; Fernández Fernández, Inmaculada (American Chemical Society, 2021)NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment ...
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Artículo
Clickable iron oxide NPs based on catechol derived ligands: synthesis and characterization
Pozo Torres, Esther; Caro Salazar, Carlos; Páez-Muñoz, José María; García-Martín, María Luisa; Fernández Fernández, Inmaculada; Pernia Leal, Manuel (Taylor and Francis Group, 2020-03-05)Clickable magnetic nanoparticles have attracted great attention as potential nanoplatforms for biomedical applications ...
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Artículo
Comprehensive Toxicity Assessment of PEGylated Magnetic Nanoparticles for in vivo applications
Caro Salazar, Carlos; Egea Benavente, David; Polvillo, Rocio; Royo, José Luis; Pernia Leal, Manuel; García-Martín, María Luisa (Elsevier, 2019-05-01)Magnetic nanoparticles (MNPs) represent one of the greatest promises for the development of a new generation of diagnostic ...
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Artículo
Deciphering the Parameters to Produce Highly Reproducible and Scalable Iron Oxide Nanoparticles
Avasthi, Ashish; Caro Salazar, Carlos; García-Martín, María Luisa; Pernia Leal, Manuel (Royal Society of Chemistry, 2023)Nanomedicine has been long hailed as a game changer for treating several ailments, but its translation from bench to bedside ...
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Tesis Doctoral
Derivados de d-Galactosa como antagonistas de los receptores NK1 de interés terapéutico: aproximaciones al diseño de nuevos nanosistemas teranósticos
Pozo Torres, Esther (2023-02-03)A pesar de los enormes esfuerzos tanto económicos como científicos invertidos en la lucha contra el cáncer, éste sigue ...
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Artículo
Fe₃ O₄-Au Core-Shell Nanoparticles as a Multimodal Platform for in Vivo Imaging and Focused Photothermal Therapy
Caro Salazar, Carlos; Gámez Márquez, Francisco; Quaresma, Pedro; Páez-Muñoz, José María; Domínguez Moreno, Alejandro; Pearson, John R.; Pernia Leal, Manuel; Beltrán, Ana M.; Fernandez-Afonso, Yilian; Fuente, Jesús M. de la; Franco, Ricardo; Pereira, Eulália; García-Martín, María Luisa (MDPI, 2021-03)In this study, we report the synthesis of gold-coated iron oxide nanoparticles capped with polyvinylpyrrolidone (Fe@Au ...
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Artículo
Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents
Caro Salazar, Carlos; Dalmases, Mariona; Figuerola, Albert; García-Martín, María Luisa; Pernia Leal, Manuel (Royal Society of Chemistry, 2017)X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that often requires intravenous ...
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Artículo
Improved non-covalent biofunctionalization of multi-walled carbon nanotubes using carbohydrate amphiphiles with a butterfly-like polyaromatic tail
Assali, Mohyeddin; Pernia Leal, Manuel; Fernández Fernández, Inmaculada; Romero Gómez, Pablo; Baati, Rachid; Khiar, Noureddine (Springer, 2010)We have developed an efficient strategy for the non-covalent functionalization of multi-walled carbon nanotubes (MWCNTs) ...
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Artículo
Magnetic Nanoparticles as MRI Contrast Agents
Avasthi, Ashish; Caro Salazar, Carlos; Pozo Torres, Esther; Pernia Leal, Manuel; García-Martín, María Luisa (Springer, 2020)Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic ...
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Artículo
Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools
Materia, Maria Elena; Pernia Leal, Manuel; Scotto, Marco; Balakrishnan, Preethi Bala; Kumar Avugadda, Sahitya; Garcı́a Martı́n, Marı́a Luisa; Cohen, Bruce E.; Chan, Emory M.; Pellegrino, Teresa (American Chemical Society, 2017)We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and ...
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Trabajo Fin de Grado
Nanomedicinas para el diagnóstico y tratamiento del glioblastoma
Garrido Díaz, Natalia (2021)El glioblastoma es considerado el tumor primario cerebral más frecuente y agresivo en adultos, siendo 15 meses la ...
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Patente
Neoglicolipidos, sus agregados con nanotubos de carbono, procedimiento de obtencion y aplicaciones
Khiar El Wahabi, Noureddine; Pernia Leal, Manuel; Fernández Fernández, Inmaculada (Oficina Española de Patentes y Marcas , 2009-11-23)La presente invención se refiere a un glicolípido de fórmula (I) en la que R es un carbohidrato seleccionado entre un ...
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Artículo
Passive targeting of high-grade gliomas via the EPR effect: a closed path for metallic nanoparticles?
Caro Salazar, Carlos; Avasthi, Ashish; Páez-Muñoz, José María; Pernia Leal, Manuel; García-Martín, María Luisa (Royal Society of Chemistry, 2021-10-28)Passive tumor targeting via the enhanced permeability and retention (EPR) effect has long been considered the most effective ...
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Artículo
PEGylated Terbium-Based Nanorods as Multimodal Bioimaging Contrast Agents
Caro Salazar, Carlos; Páez-Muñoz, José María; Beltrán, Ana M.; Pernia Leal, Manuel; García-Martín, María Luisa (American Chemical Society, 2021)Diagnostic imaging strongly relies on the use of contrast agents (CAs). In general terms, current CAs present undesirable ...
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Artículo
Scaling Up Magnetic Nanobead Synthesis with Improved Stability for Biomedical Applications
Bigall, Nadja C.; Rodio, Marina; Avugadda, Sahitya; Pernia Leal, Manuel; Di Corato, Riccardo; Conteh, John S.; Intartaglia, Romuald; Pellegrino, Teresa (American Chemical Society, 2022)The growing interest in multifunctional nano-objects based on polymers and magnetic nanoparticles for biomedical applications ...
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Artículo
Synthesis and Characterization of Elongated-Shaped Silver Nanoparticles as a Biocompatible Anisotropic SERS Probe for Intracellular Imaging: Theoretical Modeling and Experimental Verification
Caro Salazar, Carlos; Quaresma, Pedro; Pereira, Eulalia; Franco, Jaime; Pernia Leal, Manuel; García-Martín, María Luisa; Oliva Montero, José María (MDPI, 2019)Progress in the field of biocompatible SERS nanoparticles has promising prospects for biomedical applications. In this ...
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Artículo
Synthesis of 1D-glyconanomaterials by a hybrid noncovalent–covalent functionalization of single wall carbon nanotubes: a study of their selective interactions with lectins and with live cells
Pernia Leal, Manuel; Assali, Mohyeddin; Cid Martín, J.J.; Valdivia Giménez, Victoria Esther; Franco, J. M.; Fernández Fernández, Inmaculada; Pozo, D.; Khiar, Noureddine (Royal Society of Chemistry, 2015)To take full advantage of the remarkable applications of carbon nanotubes in different fields, there is a need to develop ...