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Listar por autor "Hornillos, Valentín"
Mostrando ítems 1-15 de 15
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Artículo
A Dynamic Kinetic Asymmetric Heck Reaction for the Simultaneous Generation of Central and Axial Chirality
Carmona, José A.; Hornillos, Valentín; Ramírez López, Pedro; Ros Lao, Abel; Iglesias Sigüenza, Francisco Javier; Gómez-Bengoa, Enrique; Fernández Fernández, Rosario Fátima; Lassaletta Simón, José María (American Chemical Society, 2018)A highly diastereo- and enantioselective, scalable Pd-catalyzed dynamic kinetic asymmetric Heck reaction of heterobiaryl ...
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Artículo
Asymmetric synthesis of dibenzo[b,d]azepines by Cu-catalyzed reductive or borylative cyclization
Rodríguez Salamanca, Patricia; Martín de la Calle, Rocío; Rodríguez Bravo, Verónica; Merino, Pedro; Fernández Fernández, Rosario Fátima; Lassaletta, José M.; Hornillos, Valentín (Royal Society of Chemistry, 2021)A copper-catalyzed asymmetric intramolecular reductive cyclization for the synthesis of dibenzo[b,d]azepines is described. ...
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Tesis Doctoral
Atroposelective Synthesis of (Hetero)biaryls: Dynamic Kinetic and Thermodynamic Control of the Axial Chirality
Rodríguez Salamanca, Patricia (2023-04-14)The main goal of this PhD thesis has been the development of catalytic asymmetric methodologies for the synthesis of axially ...
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Artículo
Atroposelective Synthesis of 2-(Quinolin-8-yl)benzyl Alcohols by Biocatalytic Dynamic Kinetic Resolutions
Coto Cid, Juan Manuel; Gonzalo Calvo, Gonzalo de; Carmona, José A.; Iglesias Sigüenza, Francisco Javier; Rodríguez Salamanca, Patricia; Fernández Fernández, Rosario Fátima; Hornillos, Valentín; Lassaletta, José M. (Wiley, 2023-12-22)A highly enantioselective biocatalytic dynamic kinetic resolution (DKR) of 2-(quinoline-8-yl) 3-methylbenzaldehydes and ...
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Artículo
Atroposelective transformation of axially chiral (hetero)biaryls. From desymmetrization to modern resolution strategies
Carmona, José A.; Rodríguez Franco, Carlos; Fernández Fernández, Rosario Fátima; Hornillos, Valentín; Lassaletta, José M. (Royal Society of Chemistry, 2021)This tutorial review provides a systematic overview of the available methodologies for the atroposelective transformation ...
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Artículo
Biocatalytic Atroposelective Synthesis of Axially Chiral N-Arylindoles via Dynamic Kinetic Resolution
Rodríguez Salamanca, Patricia; Gonzalo Calvo, Gonzalo de; Carmona, José A.; López Serrano, Joaquín; Iglesias Sigüenza, Francisco Javier; Fernández Fernández, Rosario Fátima; Lassaletta, José M.; Hornillos, Valentín (American Chemical Society, 2022-12-22)A highly enantioselective biocatalytic dynamic kinetic resolution (DKR) of configurationally labile N-arylindole aldehydes ...
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Artículo
Dynamic kinetic resolution of 2-(Quinolin-8-yl)benzaldehydes: atroposelective iridium-catalyzed transfer hydrogenative allylation
Carmona, José A.; Rodríguez Salamanca, Patricia; Fernández Fernández, Rosario Fátima; Lassaletta, José M.; Hornillos, Valentín (Wiley-V C H Verlag GMBH, 2023-06-30)An atroposelective Ir-catalyzed dynamic kinetic resolution (DKR) of 2-(quinolin-8- yl)benzaldehydes/1-naphthaldehydes ...
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Artículo
Dynamic Kinetic Resolution of Hetero biaryl Ketones by Zinc- Catalyzed Asymmetr ic Hydrosil ylation
Hornillos, Valentín; Carmona, José A.; Ros Lao, Abel; Iglesias Sigüenza, Francisco Javier; López Serrano, Joaquín; Fernández Fernández, Rosario Fátima; Lassaletta, José M. (Wiley, 2018)Adiastereo- and highly enantioselective dynamic kinetic resolution (DKR) of configurationally labile hetero- biaryl ketones is ...
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Artículo
Dynamic Kinetic Resolution of Indole-Based Sulfenylated Heterobiaryls by Rhodium-Catalyzed Atroposelective Reductive Aldol Reaction
Rodríguez Franco, Carlos; Ros, Abel; Merino, Pedro; Fernández Fernández, Rosario Fátima; Lassaletta, José M.; Hornillos, Valentín (Amer chemical SOC, 2023-08-30)A highly enantio- and diastereoselective dynamic kinetic resolution (DKR) of configurationally labile 3-aryl indole-2-carbaldehydes ...
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Tesis Doctoral
Dynamization strategies for the atroposelective synthesis of (hetero)biaryls
Carmona Carmona, José Alberto (2019-07-22)The central objective in this PhD thesis has been the development of asymmetric catalysis methodologies for the atroposelective ...
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Artículo
Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake
Espada, Caroline R.; Magalhães,Rubens M.; Cruz, Mario C.; Hornillos, Valentín (Elsevier, 2019)In Brazil, cutaneous leishmaniasis is caused predominantly by L. (V.) braziliensis. The few therapeutic drugs available ...
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Artículo
Ir-Catalyzed Atroposelective Desymmetrization of Heterobiaryls: Hydroarylation of Vinyl Ethers and Bicycloalkenes
Romero Arenas, Antonio; Hornillos, Valentín; Iglesias Sigüenza, Francisco Javier; Fernández Fernández, Rosario Fátima; López Serrano, Joaquín; Ros, Abel; Lassaletta, José M. (American Chemical Society, 2020)A highly regio-, diastereo-, and enantioselective, scalable Ir-catalyzed hydroarylation of electron-rich acyclic and ...
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Artículo
Pd-Catalyzed Dynamic Kinetic Asymmetric Cross-Coupling of Heterobiaryl Bromides with N-Tosylhydrazones
Kattela, Shivashankar; Roque D. Correia, Carlos; Ros, Abel; Hornillos, Valentín; Iglesias Sigüenza, Francisco Javier; Fernández Fernández, Rosario; Lassaletta Simón, José María (American Chemical Society, 2022)A dynamic kinetic asymmetric Pd-catalyzed cross-coupling reaction of heterobiaryl bromides with ketone N-tosylhydrazones ...
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Artículo
Ros3 (Lem3p/CDC50) Gene Dosage Is Implicated in Miltefosine Susceptibility in Leishmania (Viannia) braziliensis Clinical Isolates and in Leishmania (Leishmania) major
Espada, Caroline R.; Albuquerque Wendt, Andreia; Hornillos, Valentín; Gluenz, Eva; Coelho, Adriano C.; Uliana, Silvia R. B. (American Chemical Society, 2021)The Ros3 protein is a component of the MT-Ros3 transporter complex, considered as the main route of miltefosine entry in ...
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Artículo
Synthesis of axially chiral heterobiaryl alkynes via dynamic kinetic asymmetric alkynylation
Hornillos, Valentín; Ros, Abel (Wiley, 2016)The dynamic kinetic Pd0 -catalyzed alkynylation of racemic heterobiaryl sulfonates was used for the asymmetric synthesis ...