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Listar por autor "Deierborg, Tomas"
Mostrando ítems 1-17 de 17
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Artículo
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
Fernández Calle, R.; Konings, Sabine C.; Frontinan Rubio, Javier; Garcia Revilla, Juan; Camprubí Ferrer, Lluís; Svensson, Martina; Martinson, Isak; Boza Serrano, Antonio; Venero Recio, José Luis; Nielsen, Henrietta M.; Gouras, Gunnar K.; Deierborg, Tomas (Springer Nature, 2022)ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and ...
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Artículo
Caspase signalling controls microglia activation and neurotoxicity
Burguillos García, Miguel Ángel; Deierborg, Tomas; Kavanagh, Edel T.; Persson, Annette; Hajji, Nabil; García Quintanilla, Alberto; Cano, Josefina; Brundin, Patrik; Englund, Elisabet; Venero Recio, José Luis; Joseph, Bertrand (Springer Nature, 2011-04-11)Activation of microglia and inflammation-mediated neurotoxicity are suggested to play a decisive role in the pathogenesis ...
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Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease
Tayara, Khadija; Espinosa Oliva, Ana María; García Domínguez, Irene; Ismaiel, Afrah Abdul; Boza Serrano, Antonio; Deierborg, Tomas; Martínez de Pablos, Rocío; Machado de la Quintana, Alberto; Herrera Carmona, Antonio José; Venero Recio, José Luis (Frontiers Media, 2018)The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, ...
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Artículo
Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner
Bachiller, Sara; Hidalgo, Isabel; Garcia, M. G.; Boza Serrano, Antonio; Paulus, Agnes; Denis, Q.; Haikal, C.; Manouchehrian, O.; Klementieva, O.; Li, J. Y.; Pronk, C. J.; Gouras, G. K.; Deierborg, Tomas (BMC, 2022)Background The risk of developing Alzheimer’s disease (AD) is modulated by genetic and environmental factors. Early-life ...
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Artículo
Galectin-3 depletion tames pro-tumoural microglia and restrains cancer cells growth
Rivera Ramos, Alberto; Cruz Hernández, Luis; Talaverón Aguilocho, Rocío; Sánchez Montero, María Teresa; García Revilla, Juan; Mulero Acevedo, Marta; Deierborg, Tomas; Venero Recio, José Luis; Sarmiento Soto, Manuel (Elsevier, 2024-04-16)Galectin-3 (Gal-3) is a multifunctional protein that plays a pivotal role in the initiation and progression of various ...
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Galectin-3 is elevated in CSF and is associated with A beta deposits and tau aggregates in brain tissue in Alzheimer's disease
Boza Serrano, Antonio; Vrillon, Agathe; Minta, Karolina; Paulus, Agnes; Camprubí Ferrer, Lluís; García, Megg; Vitorica Ferrández, Francisco Javier; Venero Recio, José Luis; Deierborg, Tomas (Springer, 2022)Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous ...
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Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
García Revilla, Juan; Boza Serrano, Antonio; Espinosa Oliva, Ana María; Sarmiento Soto, Manuel; Deierborg, Tomas; Ruiz Laza, Rocío; Martínez de Pablos, Rocío; Burguillos García, Miguel Ángel; Venero Recio, José Luis (Springer Nature, 2022)The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are ...
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Artículo
Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease
Boza Serrano, Antonio; Ruíz Laza, Rocio; Sánchez Varo, Raquel María; García Revilla, Juan; Yang, Yiyi; Jiménez Ferrer, Itzia; Jiménez Muñoz, Sebastián; Roca Ceballos, María Angustias; Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Venero Recio, José Luis; Deierborg, Tomas (Springer, 2019)Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of ...
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Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider
García Revilla, Juan; Deierborg, Tomas; Venero Recio, José Luis; Boza Serrano, Antonio (Frontiers Media, 2020)COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any ...
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LPS priming before plaque deposition impedes microglial activation and restrains Abeta pathology in the 5xFAD mouse model of Alzheimer's disease.
Yang, Yiyi; García Cruzado, Marta; Zeng, Hairuo; Camprubi Ferrer, Lluis; Bahatyrevich Kharitonik, Bazhena; Bachiller, Sara; Deierborg, Tomas (Elsevier, 2023-10)Microglia have an innate immunity memory (IIM) with divergent functions in different animal models of neurodegenerative ...
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Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation
Burguillos García, Miguel Ángel; Svensson, Martina; Schulte, Tim; Boza Serrano, Antonio; García Quintanilla, Alberto; Kavanagh, Edel T.; Santiago Pavón, Martiniano; Viceconte, Nikenza; Oliva Martín, María José; Osman, Ahmed Mohamed; Salomonsson, Emma; Amar, Lahouari; Persson, Annette; Blomgren, Klas; Achour, Adnane; Englund, Elisabet; Leffler, Hakon; Venero Recio, José Luis; Joseph, Bertrand; Deierborg, Tomas (2015)Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory ...
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Artículo
Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease
Bachiller, Sara; Ruiz Laza, Rocío; Boza Serrano, Antonio; Rodríguez-Moreno, Antonio; Deierborg, Tomas; Fisahn, André (2023)Background Alzheimer’s disease (AD) is a progressive multifaceted neurodegenerative disorder for which no disease-modifying ...
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Artículo
The human bone marrow harbors a CD45− CD11B+ cell progenitor permitting rapid microglia-like cell derivative approaches
Bruzelius, Andreas; Hidalgo, Isabel; Boza Serrano, Antonio; Hjelmér, Anna Giorgia; Tison, Amelie; Deierborg, Tomas; Bengzon, Johan; Ramos Moreno, Tania (Wiley-Blackwell, 2021)Microglia, the immune sentinel of the central nervous system (CNS), are generated from yolk sac erythromyeloid progenitors ...
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The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients
Alonso Bellido, Isabel María; Bachiller, Sara; Vázquez, Guillermo; Cruz Hernández, Luis; Martínez, Emilio; Ruiz Mateos, Ezequiel; Deierborg, Tomas; Venero Recio, José Luis; Real, Luis Miguel; Ruiz Laza, Rocío (Frontiers Media S.A., 2021)The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease ...
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Tesis Doctoral
The role of Galectin-3 in the pathogenesis of Parkinson's Disease
García Revilla, Juan (2019-12-20)En 1817, James Parkinson describió por primera vez un conjunto de síntomas motores en el ensayo titulado “Shaking Palsy” ...
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The role of Galectin-3 in α-synuclein-induced microglial activation
Boza Serrano, Antonio; Reyes, Juan F.; Rey, Nolwen L.; Leffler, Hakon; Bousset, Luc; Nilsson, Ulf J.; Brundin, Patrik; Venero Recio, José Luis; Burguillos García, Miguel Ángel; Deierborg, Tomas (BioMed Central, 2014)Background: Parkinson ’ s disease (PD) is the most prevalent neurodegenerative motor disorder. The neuropathology ...
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Artículo
The Ubiquitin Proteasome System in Neuromuscular Disorders: Moving Beyond Movement
Bachiller, Sara; Alonso Bellido, Isabel María; Real, Luis Miguel; Pérez Villegas, Eva María; Venero Recio, José Luis; Deierborg, Tomas; Armengol, José Ángel; Ruiz Laza, Rocío (Multidisciplinary Digital Publishing Institute (MDPI), 2020)Neuromuscular disorders (NMDs) affect 1 in 3000 people worldwide. There are more than 150 different types of NMDs, where ...