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Listar por autor "Díaz Moreno, Irene"
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Artículo
Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors
Lachiondo Ortega, Sofía; Cardoso Delgado, Teresa; Baños Jaime, Blanca; Velázquez Cruz, Alejandro; Díaz Moreno, Irene; Martínez Chantar, María Luz (MDPI, 2022)Hepatobiliary tumors are a group of primary malignancies encompassing the liver, the intra- and extra-hepatic biliary ...
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HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs
García Mauriño, Sofía M.; Pabis, M; Popowicz, GM; Asami S; Díaz Moreno, Irene (Oxford University Press, 2019)HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing ...
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HuR thermal stability is dependent on domain binding and upon phosphorylation
Scheiba, Rafael Manfred; Aroca Aguilar, Ángeles; Díaz Moreno, Irene (Springer, 2012)Human antigen R (HuR) is a multitasking RNA binding protein involved in posttranscriptional regulation by recognizing ...
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Inhibition of the PP2A activity by the histone chaperone ANP32B is long-range allosterically regulated by respiratory cytochrome c
Rivero Rodríguez, Francisco; Díaz Quintana, Antonio Jesús; Velázquez Cruz, Alejandro; González Arzola, Katiuska; Gavilán Dorronzoro, María de la Paz; Velázquez Campoy, Adrián; Ríos Sánchez, Rosa María; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Elsevier, 2021)Repair of injured DNA relies on nucleosome dismantling by histone chaperones and de-phosphorylation events carried out by ...
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Key Role of the Local Hydrophobicity in the East Patch of Plastocyanins on Their Thermal Stability and Redox Properties
Olloqui Sariego, José Luis; Márquez Escudero, Inmaculada; Frutos Beltrán, Estrella; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la; Calvente Pacheco, Juan José; Andreu Fondacabe, Rafael Jesús; Díaz Quintana, Antonio Jesús (American Chemical Society, 2018)Understanding the molecular basis of the thermal stability and functionality of redox proteins has important practical ...
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Long distance electron transfer through the aqueous solution between redox partner proteins
Lagunas, Anna; Guerra Castellano, Alejandra; Nin Hill, Alba; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la; Samitier, Josep; Rovira, Carme; Gorostiza, Pau (Nature Research, 2018)Despite the importance of electron transfer between redox proteins in photosynthesis and respiration, the inter-protein ...
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Lysosomes: multifunctional compartments ruled by a complex regulatory network
Martínez Fábregas, Jonathan; Tamargo Azpilicueta, Joaquín; Díaz Moreno, Irene (Wiley, 2022)More than 50 years have passed since Nobel laureate Cristian de Duve described for the first time the presence of tiny ...
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Tesis Doctoral
Mechanistic insights into the post-translational regulation of RNA-binding proteins in cell life and disease
Velázquez Cruz, Alejandro (2024-02-01)Cell signaling networks modulate gene expression in response to internal and external stimuli. Rapid cellular adaptation ...
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Membraneless organelles: a smart design for metabolic control
Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la (Wiley Online Library, 2021)While most organelles are surrounded by membranes, cells also contain membraneless organelles, which remain separated in ...
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Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus
González Arzola, Katiuska; Guerra Castellano, Alejandra; Rivero Rodríguez, Francisco; Casado Combreras, Miguel Ángel; Pérez Mejías, Gonzalo; Díaz Quintana, Antonio Jesús; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la (Wiley-Blackwell, 2021)Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually ...
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Modulation of copper site properties by remote residues determines the stability of plastocyanins
Muñoz López, Francisco Jesús; Frutos Beltrán, Estrella; Díaz Moreno, Sofía; Díaz Moreno, Irene; Subías Peruga, Maria Gloria; Rosa Acosta, Miguel Ángel de la; Díaz Quintana, Antonio Jesús (Elsevier, 2010)The metal cofactor determines the thermal stability in cupredoxins, but how the redox state of copper modulates their ...
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Molecular basis of FIR-mediated c-myc transcriptional control
Cukier, Cyprian D.; Hollingworth, David; Martin, Stephen; Kelly, Geoff; Díaz Moreno, Irene; Ramos, Andrés (Nature Research, 2010)The far upstream element (FUSE) regulatory system promotes a peak in the concentration of c-Myc during cell cycle. First, ...
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Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
González Rellán, María J.; Fernández, Uxía; Parracho, Tamara; Novoa, Eva; Fondevila, Marcos F.; Da Silva Lima, Natalia; Rodríguez, Amaia; Pérez Mejías, Gonzalo; Díaz Quintana, Antonio Jesús; Díaz Moreno, Irene; Nogueiras, Rubén (Elsevier, 2023)Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed ...
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New Arabidopsis thaliana cytochrome c partners: A look into the elusive role of cytochrome c in programmed cell death in plants
Martínez Fábregas, Jonathan; Díaz Moreno, Irene; González Arzola, Katiuska; Janocha, Simon; Navarro Carruesco, José Antonio; Hervás Morón, Manuel; Bernhardt, Rita; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (American Society for Biochemistry and Molecular Biology, 2013)Programmed cell death is an event displayed by many different organisms along the evolutionary scale. In plants, programmed ...
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Nicotinamide N-methyltransferase (NNMT) regulates the glucocorticoid signaling pathway during the early phase of adipogenesis
Roberti, Annalisa; Tejedor, Juan Ramón; Díaz Moreno, Irene; López, Virginia; Santamarina-Ojeda, Pablo; Pérez, Raúl F.; Urdinguio, Rocío G.; Concellón, Carmen; Martínez-Chantar, María Luz; Fernández Morera, Juan Luis; Díaz Quintana, Antonio Jesús; Amo, Vicente del; Fernández, Agustín F.; Fraga, Mario F. (Springer Nature, 2023-05-22)Obesity is associated with adipose tissue dysfunction through the differentiation and expansion of pre-adipocytes to ...
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Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation
García Heredia, José Manuel; Díaz Moreno, Irene; Nieto Mesa, Pedro Manuel; Orzáez, Mar; Kocanis, Stella; Teixeira, Miguel; Pérez Payá, Enrique; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Elsevier, 2010)Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure ...
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Artículo
NMR analysis of the transient complex between membrane photosystem I and soluble cytochrome c6
Díaz Moreno, Irene; Díaz Quintana, Antonio Jesús; Molina Heredia, Fernando Publio; Nieto Mesa, Pedro Manuel; Hansson, Örjan; Rosa Acosta, Miguel Ángel de la; Karlsson, B. Göran (Elsevier, 2005)A structural analysis of the surface areas of cytochrome c6, responsible for the transient interaction with photosystem ...
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Tesis Doctoral
Novel insights into the mechanism of electron transfer in mitochondrial cytochrome c and its regulation by post-translational modifications
Pérez Mejías, Gonzalo (2023-06-30)Las células que componen nuestro cuerpo obtienen la mayor parte de la energía que necesitan para vivir, de los alimentos ...
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Nuclear cytochrome c – a mitochondrial visitor regulating damaged chromatin dynamics
Díaz Moreno, Irene; Velázquez Cruz, Alejandro; Curran French, Seamus; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Wiley-Blackwell, 2018)Over the past decade, evidence has emerged suggesting a broader role for cytochrome c (Cyt c) in programmed cell death. ...
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Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation.
González Arzola, Katiuska; Díaz Quintana, Antonio Jesús; Bernardo García, Noelia; Martínez Fábregas, Jonathan; Rivero Rodríguez, Francisco; Casado Combreras, Miguel Ángel; Elena-Real, Carlos A.; Velázquez Cruz, Alejandro; Gil Caballero, Sergio; Velázquez Campoy, Adrián; Szulc, Elzbieta; Gavilán Dorronzoro, María de la Paz; Ayala, Isabel; Arranz, Rocío; Ríos, Rosa M.; Salvatella, Xavier; Valpuesta, José María; Hermoso, Juan A.; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Nature Research, 2022-10-11)The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered unrelated processes, yet ...