dc.creator | López Martín, Sergio | es |
dc.creator | Rodríguez Gallardo, Sofía | es |
dc.creator | Sabido Bozo, Susana | es |
dc.creator | Muñiz Guinea, Manuel | es |
dc.date.accessioned | 2019-08-23T11:55:51Z | |
dc.date.available | 2019-08-23T11:55:51Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | López Martín, S., Rodríguez Gallardo, S., Sabido Bozo, S. y Muñiz Guinea, M. (2019). Endoplasmic Reticulum Export of GPI-Anchored Proteins. International Journal of Molecular Sciences, 20 (14), 3506. | |
dc.identifier.issn | 1661-6596 | es |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://hdl.handle.net/11441/88640 | |
dc.description.abstract | Protein export from the endoplasmic reticulum (ER) is an essential process in all eukaryotes
driven by the cytosolic coat complex COPII, which forms vesicles at ER exit sites for transport
of correctly assembled secretory cargo to the Golgi apparatus. The COPII machinery must adapt
to the existing wide variety of different types of cargo proteins and to different cellular needs for
cargo secretion. The study of the ER export of glycosylphosphatidylinositol (GPI)-anchored proteins
(GPI-APs), a special glycolipid-linked class of cell surface proteins, is contributing to address these
key issues. Due to their special biophysical properties, GPI-APs use a specialized COPII machinery
to be exported from the ER and their processing and maturation has been recently shown to actively
regulate COPII function. In this review, we discuss the regulatory mechanisms by which GPI-APs are
assembled and selectively exported from the ER. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad de España (MINECO)-BFU2017-89700-P | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | International Journal of Molecular Sciences, 20 (14), 3506. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | endoplasmic reticulum | es |
dc.subject | COPII coat | es |
dc.subject | GPI-anchored protein | es |
dc.subject | p24 complex | es |
dc.title | Endoplasmic Reticulum Export of GPI-Anchored Proteins | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.relation.projectID | BFU2017-89700-P | es |
dc.relation.publisherversion | https://doi.org/10.3390/ijms20143506 | es |
dc.identifier.doi | 10.3390/ijms20143506 | es |
idus.format.extent | 16 p. | es |
dc.journaltitle | International Journal of Molecular Sciences | es |
dc.publication.volumen | 20 | es |
dc.publication.issue | 14 | es |
dc.publication.initialPage | 3506 | es |