dc.creator | Gonzalo Gobernado, Rafael | es |
dc.creator | Ayuso, María Irene | es |
dc.creator | Sansone, Loredana | es |
dc.creator | Bernal Jiménez, Juan José | es |
dc.creator | Ramos Herrero, Víctor Darío | es |
dc.creator | Sánchez García, Enrique | es |
dc.creator | Ramos, Teresa L. | es |
dc.creator | Abia González, María del Rocío | es |
dc.creator | García Muriana, Francisco José | es |
dc.creator | Bermúdez Pulgarín, Beatriz | es |
dc.creator | Montaner, Joan | |
dc.date.accessioned | 2019-07-05T11:17:13Z | |
dc.date.available | 2019-07-05T11:17:13Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Bermúdez Pulgarín, B., Gonzálo Gobernado, R., Ayuso, M.I., Sansone, L., Bernal Jiménez, J.J., Ramos Herrero, V.D.,...,Abia González, M.d.R. (2019). Neuroprotective Effects of Diets Containing Olive Oil and DHA/EPA in a Mouse Model of Cerebral Ischemia. Nutrients, 11 (5), 1-17. | |
dc.identifier.issn | 2072-6643 | es |
dc.identifier.uri | https://hdl.handle.net/11441/87890 | |
dc.description.abstract | Stroke is one of the leading causes of death worldwide and while there is increasing evidence that a Mediterranean diet might decrease the risk of a stroke, the effects of dietary fat composition on stroke outcomes have not been fully explored. We hypothesize that the brain damage provoked by a stroke would be different depending on the source of dietary fat. To test this, male C57BL/6J mice were fed for 4 weeks with a standard low-fat diet (LFD), a high-fat diet (HFD) rich in saturated fatty acids (HFD-SFA), an HFD containing monounsaturated fatty acids (MUFAs) from olive oil (HFD-OO), or an HFD containing MUFAs from olive oil plus polyunsaturated fatty acids (PUFAs) docosahexaenoic acid/eicosapentaenoic acid (DHA/EPA) (HFD-OO-ω3). These mice were then subjected to transient middle cerebral artery occlusion (tMCAo). Behavioural tests and histological analyses were performed 24 and/or 48 h after tMCAo in order to elucidate the impact of these diets with different fatty acid profiles on the ischemic lesion and on neurological functions. Mice fed with HFD-OO-ω3 displayed better histological outcomes after cerebral ischemia than mice that received an HFD-SFA or LFD. Furthermore, PUFA- and MUFA-enriched diets improved the motor function and neurological performance of ischemic mice relative to those fed with an LFD or HFD-SFA. These findings support the use of DHA/EPA-omega-3-fatty acid supplementation and olive oil as dietary source of MUFAs in order to reduce the damage and protect the brain when a stroke occurs | es |
dc.description.sponsorship | España, Consejería de Salud de la Junta de Andalucía, grants PI-0114-2016 and PI-0024-2018. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Nutrients, 11 (5), 1-17. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | DHA | es |
dc.subject | EPA | es |
dc.subject | MUFA | es |
dc.subject | PUFA | es |
dc.subject | SFA | es |
dc.subject | behaviour | es |
dc.subject | cerebral ischemia | es |
dc.subject | middle cerebral artery occlusion (MCAo) | es |
dc.subject | neurological function | es |
dc.subject | neuroprotection | es |
dc.subject | olive oil | es |
dc.subject | omega-3 fatty acids | es |
dc.subject | stroke | es |
dc.title | Neuroprotective Effects of Diets Containing Olive Oil and DHA/EPA in a Mouse Model of Cerebral Ischemia | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.relation.projectID | PI-0114-2016 | es |
dc.relation.projectID | PI-0024-2018 | es |
dc.relation.publisherversion | http://dx.doi.org/10.3390/nu11051109 | es |
dc.identifier.doi | 10.3390/nu11051109 | es |
idus.format.extent | 17 p. | es |
dc.journaltitle | Nutrients | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 17 | es |