dc.creator | Iglesias, N. | es |
dc.creator | Galbis Fuster, Elsa | es |
dc.creator | Valencia, Concepción | es |
dc.creator | Paz Báñez, María Violante de | es |
dc.creator | Galbis Pérez, Juan Antonio | es |
dc.date.accessioned | 2018-05-22T08:15:36Z | |
dc.date.available | 2018-05-22T08:15:36Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Iglesias, N., Galbis Fuster, E., Valencia, C., Paz Bañez, M.V.d. y Galbis Pérez, J.A. (2018). Reversible pH-sensitive chitosan-based hydrogels. Influence of dispersion composition on rheological properties and sustained drug delivery. Polymers, 10 (4), 392. | |
dc.identifier.issn | 2073-4360 | es |
dc.identifier.uri | https://hdl.handle.net/11441/74889 | |
dc.description.abstract | The present work deals with the synthesis of micro-structured biomaterials based on
chitosan (CTS) for their applications as biocompatible carriers of drugs and bioactive compounds.
Twelve dispersions were prepared by means of functional cross-linking with tricarballylic acid (TCA);
they were characterized by Fourier transform infrared spectroscopy (FT-IR), modulated temperature
differential scanning calorimetry (MTDSC) and scanning electron microscopy (SEM), and their
rheological properties were studied. To the best of the authors’ knowledge, no study has been
carried out on the influence of CTS concentration, degree of cross-linking and drug loading
on chitosan hydrogels for drug delivery systems (DDS) and is investigated herein for the first
time. The influence of dispersion composition (polymer concentration and degree of cross-linking)
revealed to exert a marked impact on its rheological properties, going from liquid-like to
viscoelastic gels. The release profiles of a model drug, diclofenac sodium (DCNa), as well as their
relationships with polymer concentration, drug loading and degree of cross-linking were evaluated.
Similar to the findings on rheological properties, a wide range of release profiles was encountered.
These formulations were found to display a well-controlled drug release strongly dependent on the
formulation composition. Cumulative drug release under physiological conditions for 96 h ranged
from 8% to 67%. For comparative purpose, Voltaren emulgel® from Novartis Pharmaceuticals was
also investigated and the latter was the formulation with the highest cumulative drug release (85%).
Some formulations showed similar spreadability values to the commercial hydrogel. The comparative
study of three batches confirmed the reproducibility of the method, leading to systems particularly
suitable for their use as drug carriers. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad MAT2016-77345-C3-2-P | es |
dc.description.sponsorship | Junta de Andalucía P12-FQM-1553 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Polymers, 10(4), 392. | |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Ionic cross-linking | es |
dc.subject | Eco-friendly formulations | |
dc.subject | Thermal transition sol-gel | |
dc.subject | Drug delivery systems | |
dc.subject | MTDSC | |
dc.subject | DSC | |
dc.title | Reversible pH-sensitive chitosan-based hydrogels. Influence of dispersion composition on rheological properties and sustained drug delivery | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ingeniería Química | es |
dc.relation.projectID | MAT2016-77345-C3-2-P | es |
dc.relation.projectID | P12-FQM-1553 | es |
dc.relation.publisherversion | https://doi.org/10.3390/polym10040392 | es |
dc.identifier.doi | 10.3390/polym10040392 | es |
idus.format.extent | 17 | es |
dc.journaltitle | Polymers | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 392 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | |
dc.contributor.funder | Junta de Andalucía | |