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Insights into metabolic osmoadaptation of the ectoines-producer bacterium Chromohalobacter salexigens through a high-quality genome scale metabolic model

Opened Access Insights into metabolic osmoadaptation of the ectoines-producer bacterium Chromohalobacter salexigens through a high-quality genome scale metabolic model

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Autor: Piubeli, Francine
Salvador de Lara, Manuel
Argandoña Bertrán, Montserrat
Nieto Gutiérrez, Joaquín José
Bernal, Vicente
Pastor, José M.
Cánovas, Manuel
Vargas Macías, Carmen
Departamento: Universidad de Sevilla. Departamento de Microbiología y Parasitología
Fecha: 2018
Publicado en: Microbial Cell Factories
Tipo de documento: Artículo
Resumen: Background The halophilic bacterium Chromohalobacter salexigens is a natural producer of ectoines, compatible solutes with current and potential biotechnological applications. As production of ectoines is an osmoregulated process that draws away TCA intermediates, bacterial metabolism needs to be adapted to cope with salinity changes. To explore and use C. salexigens as cell factory for ectoine(s) production, a comprehensive knowledge at the systems level of its metabolism is essential. For this purpose, the construction of a robust and high-quality genome-based metabolic model of C. salexigens was approached. Results We generated and validated a high quality genome-based C. salexigens metabolic model (iFP764). This comprised an exhaustive reconstruction process based on experimental information, analysis of genome sequence, manual re-annotation of metabolic genes, and in-depth refinement. The model included three compartments (periplasmic, cytoplasmic and external medium), and...
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Cita: Piubeli, F., Salvador de Lara, M., Argandoña Bertrán, M., Nieto Gutiérrez, J.J., Bernal, V., Pastor, J.M.,...,Vargas Macías, C. (2018). Insights into metabolic osmoadaptation of the ectoines-producer bacterium Chromohalobacter salexigens through a high-quality genome scale metabolic model. Microbial Cell Factories
Tamaño: 2.679Mb
Formato: PDF

URI: https://hdl.handle.net/11441/74673

DOI: 10.1186/s12934-017-0852-0

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