NameVargas Macías, Carmen
DepartmentMicrobiología y Parasitología
Knowledge areaMicrobiología
Professional categoryCatedrática de Universidad
E-mailRequest
           
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PhD Thesis
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Systems metabolic engineering in the halophilic bacteria Chromohalobacter salexigens for overproduction of ectoines

Martínez Martínez, Lourdes; Argandoña Bertrán, Montserrat; Vargas Macías, Carmen (2022)
The halophilic broad salt-gi owing bacterium Nfiromofio/o#octer solezipens is a natui al producer of ectoines, compatible ...
PhD Thesis
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Estudio de los metalorreguladores Fur en la bacteria extremófila Chromohalobacter salexigens: implicación en la homeostasis del hierro y en la síntesis de ectoínas

Naranjo Fernández, Emilia; Argandoña Bertrán, Montserrat; Vargas Macías, Carmen (2021)
Chromohalobacter salexigens es un microorganismo extremófilo modelo de máximo interés y aplicabilidad en Biotecnología ...
Article
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New insights into hydroxyectoine synthesis and its transcriptional regulation in the broad-salt growing halophilic bacterium Chromohalobacter salexigens

Argandoña Bertrán, Montserrat; Piubeli, Francine; Reina Bueno, Mercedes; Nieto Gutiérrez, Joaquín José; Vargas Macías, Carmen (Wiley-Blackwell, 2021)
Elucidating the mechanisms controlling the synthesis of hydroxyectoine is important to design novel genetic engineering ...
PhD Thesis
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Redes de señalización implicadas en la regulación del metabolismo de las ectoínas en la bacteria halófila Chromohalobacter salexigens y su potencial terapéutico como agente neuroprotector

García Valero, Rosa María; Argandoña Bertrán, Montserrat; Vargas Macías, Carmen (2020)
Chromohalobacter salexigens is a halophilic bacterium which naturally produces ectoine and hydroxyectoine, two biotechnologically ...
Article
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Fructose metabolism in Chromohalobacter salexigens: interplay between the Embden–Meyerhof–Parnas and Entner–Doudoroff pathways

Pastor, José M.; Borges, Nuno; Pagán, Juan P.; Castaño Cerezo, Sara; Csonka, Laszlo N.; Goodner, Bradley W.; Reynolds, Kathryn A.; Gonçalves, Luís G.; Argandoña Bertrán, Montserrat; Nieto Gutiérrez, Joaquín José; Vargas Macías, Carmen; Bernal, Vicente; Cánovas, Manuel (BMC, 2019)
Background The halophilic bacterium Chromohalobacter salexigens metabolizes glucose exclusively through the Entner–Doudoroff ...
Article
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Insights into metabolic osmoadaptation of the ectoines-producer bacterium Chromohalobacter salexigens through a high-quality genome scale metabolic model

Piubeli, Francine; Salvador de Lara, Manuel; Argandoña Bertrán, Montserrat; Nieto Gutiérrez, Joaquín José; Bernal, Vicente; Pastor, José M.; Cánovas, Manuel; Vargas Macías, Carmen (BioMed Central, 2018)
Background The halophilic bacterium Chromohalobacter salexigens is a natural producer of ectoines, compatible solutes ...
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Quantitative RNA-seq Analysis Unveils Osmotic and Thermal Adaptation Mechanisms Relevant for Ectoine Production in Chromohalobacter salexigens

Salvador de Lara, Manuel; Argandoña Bertrán, Montserrat; Naranjo Fernández, Emilia; Piubeli, Francine; Nieto Gutiérrez, Joaquín José; Vargas Macías, Carmen (Frontiers Media, 2018)
Quantitative RNA sequencing (RNA-seq) and the complementary phenotypic assays were implemented to investigate the ...
Patent. Invention
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Uso de la ectoína o sus derivados como agentes antiinflamantorios y/o antioxidantes en enfermedades causadas por la formacion de agregados proteicos

Salvador de Lara, Manuel; García Valero, Rosa María; Argandoña Bertran, Montserrat; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Nieto Gutiérrez, Joaquín José; Vargas Macías, Carmen (Oficina Española de Patentes y Marcas (OEPM), 2017)
Uso de la ectoína o sus derivados como agentes antiinflamatorios y/o antioxidantes en enfermedades causadas por la formación ...
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Understanding the interplay of carbon and nitrogen supply for ectoines production and metabolic overflow in high density cultures of Chromohalobacter salexigens

Salar García, María J.; Bernal, Vicente; Pastor, José M.; Salvador de Lara, Manuel; Argandoña Bertrán, Montserrat; Nieto Gutiérrez, Joaquín José; Vargas Macías, Carmen (BioMed Central, 2017)
Background The halophilic bacterium Chromohalobacter salexigens has been proposed as promising cell factory for the ...
Article
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The global response regulator RegR controls expression of denitrification genes in Bradyrhizobium japonicum

Torres, María J.; Argandoña Bertrán, Montserrat; Vargas Macías, Carmen; Bedmar, Eulogio José; Fischer, Hans Martin; Mesa, Socorro; Delgado, María Jesús (Public Library of Science, 2014)
Bradyrhizobium japonicum RegSR regulatory proteins belong to the family of two-component regulatory systems, ...
Article
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Role of central metabolism in the osmoadaptation of the halophilic bacterium chromohalobacter salexigens

Pastor, José M.; Bernal, Vicente; Salvador de Lara, Manuel; Argandoña Bertrán, Montserrat; Vargas Macías, Carmen; Csonka, Laszlo N.; Sevilla, Ángel; Iborra, José Luis; Nieto Gutiérrez, Joaquín José; Cánovas, Manuel (American Society for Biochemistry and Molecular Biology Inc., 2013)
Bacterial osmoadaptation involves the cytoplasmic accumulation of compatible solutes to counteract extracellular osmolarity. ...
Article
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Role of trehalose in heat and desiccation tolerance in the soil bacterium Rhizobium etli

Reina Bueno, Mercedes; Hidalgo García, Alba; Delgado Igeño, María Jesús; Iglesias Guerra, Fernando; Argandoña Bertrán, Montserrat; Vargas Macías, Carmen; Nieto Gutiérrez, Joaquín José (2012)
Article
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Temperature- and salinity-decoupled overproduction of hydroxyectoine by chromohalobacter salexigens

Nieto Gutiérrez, Joaquín José; Rodríguez Moya, Javier; Argandoña Bertrán, Montserrat; Iglesias Guerra, Fernando; Vargas Macías, Carmen (American Society for Microbiology, 2012)
Hydroxyectoine overproduction by the natural producer Chromohalobacter salexigens is presented in this study. Genetically ...
Article
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Role of Trehalose in Salinity and Temperature Tolerance in the Model Halophilic Bacterium Chromohalobacter salexigens

Nieto Gutiérrez, Joaquín José; Salvador de Lara, Manuel; Rodríguez de Moya Vera, Javier; Argandoña Bertrán, Montserrat; Iglesias Guerra, Fernando; Csonka, Laszlo N.; Reina Bueno, Mercedes; Vargas Macías, Carmen (2012)
Book
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Guía del Farmacéutico Tutor de Farmacia Hospitalaria

Orta Cuevas, María del Mar; Sánchez Burson, Jesús Luis; García Jiménez, Eduardo; Alarcón de la Lastra Romero, Catalina; Jos Gallego, Ángeles Mencía; Vargas Macías, Carmen; García Asuero, Agustín; Vega Pérez, José Manuel (Universidad de Sevilla. Facultad de Farmacia, 2011)
Article
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Complete genome sequence of the halophilic and highly halotolerant Chromohalobacter salexigens type strain (1H11 T) 

Nieto Gutiérrez, Joaquín José; Copeland, Alex C.; O'Connor, Kathleen A.; Lucas, Susan M.; Lapidus, Alla L.; Berry, Kerrie W.; Detter, John Chris; Rio, Tijana Glavina del; Hammon, Nancy M; Dalin, Eileen; Tice, Hope N.; Pit-Luck, Sam; Bruce, David C.; Goodwin, Lynne A.; Han, Cliff; Tapia, Roxanne; Saund-Ers, Elizabeth; Schmutz, Jeremy; Brettin, Thomas S.; Larimer, Frank W.; Land, Miriam; Hauser, Loren J.; Vargas Macías, Carmen; Kyrpides, Nikos C.; Ivanova, Natalia N.; Göker, Markus; Klenk, Hans Peter; Csonka, Laszlo N.; Woyke, Tanja (Michigan State University, 2011)
Chromohalobacter salexigens is one of nine currently known species of the genus Chromohalobacter in the family Halomonadaceae. ...
Article
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Biosynthesis of compatible solutes in rhizobial strains isolated from Phaseolus vulgaris nodules in Tunisian fields

Fernández Aunión, Cristina; Ben Hamouda, Thouraya; Vargas Macías, Carmen; Argandoña Bertrán, Montserrat; Iglesias Guerra, Fernando; Reina Bueno, Mercedes; Elarbi Aouan, M.; Nieto Gutiérrez, Joaquín José (2010)
Article
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Interplay between iron homeostasis and the osmotic stress response in the halophilic bacterium Chromohalobacter salexigens

Nieto Gutiérrez, Joaquín José; Argandoña Bertrán, Montserrat; Iglesias Guerra, Fernando; Calderón, María Isabel; García Estepa, Raúl; Vargas Macías, Carmen (American Society for Microbiology, 2010)
In this study, the connection between iron homeostasis and the osmostress response in the halophile Chromohalobacter ...
Article
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Involvement of EupR, a response regulator of the NarL/FixJ family, in the control of the uptake of the compatible solutes ectoines by the halophilic bacterium chromohalobacter salexigens

Reina Bueno, Mercedes; Argandoña Bertrán, Montserrat; Vargas Macías, Carmen; Nieto Gutiérrez, Joaquín José; Jebbar, Mohamed; Rodríguez de Moya Vera, Javier; Iglesias Guerra, Fernando (2010)
Article
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Unravelling the adaptation responses to osmotic and temperature stress in Chromohalobacter salexigens, a bacterium with broad salinity tolerance

Nieto Gutiérrez, Joaquín José; Vargas Macías, Carmen; Argandoña Bertrán, Montserrat; Reina Bueno, Mercedes; Rodríguez Moya, Javier; Fernández Aunión, Cristina (BioMed Central, 2008)
Chromohalobacter salexigens, a Gammaproteobacterium belonging to the family Halomonadaceae, shows a broad salinity range ...
Article
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The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens

Nieto Gutiérrez, Joaquín José; García Estepa, Raúl; Argandoña Bertrán, Montserrat; Reina Bueno, Mercedes; Capote Maínez, María Nieves; Iglesias Guerra, Fernando; Vargas Macías, Carmen (American Society for Microbiology, 2006)
The halophilic bacterium Chromohalobacter salexigens synthesizes and accumulates compatible solutes in response to salt ...
PhD Thesis
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Genética de solutos compatibles en bacterias halófilas moderada

Calderón Rodríguez, Maria Isabel; Nieto Gutiérrez, Joaquín José; Vargas Macías, Carmen (2002)
Article
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Role of Nγ-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine

Nieto Gutiérrez, Joaquín José; Cánovas López, David; Borges, Nuno; Vargas Macías, Carmen; Ventosa Ucero, Antonio; Santos, Helena (American Society for Microbiology, 1999)
Strain CHR63 is a salt-sensitive mutant of the moderately halophilic wild-type strain Halomonas elongata DSM 3043 that is ...
Article
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Synthesis of glycine betaine from exogenous choline in the moderately halophilic bacterium Halomonas elongata

Nieto Gutiérrez, Joaquín José; Cánovas López, David; Vargas Macías, Carmen; Csonka, Laszlo N.; Ventosa Ucero, Antonio (American Society for Microbiology, 1998)
The role of choline in osmoprotection in the moderate halophile Halomonas elongata has been examined. Transport and ...
PhD Thesis
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Bases moleculares de los mecanismos de osmorregulación en bacterias halófilas moderadas

Cánovas López, David; Nieto Gutiérrez, Joaquín José; Ventosa Ucero, Antonio; Vargas Macías, Carmen (1998)
Durante la última década, nuestro Equipo de Investigación ha realizado numerosos estudios encaminados a un mejor conocimiento ...
Article
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Isolation and characterization of salt-sensitive mutants of the moderate halophile Halomonas elongata and cloning of the ectoine synthesis genes

Cánovas López, David; Vargas Macías, Carmen; Iglesias Guerra, Fernando; Csonka, Laszlo N.; Rhodes, David R.; Ventosa Ucero, Antonio; Nieto Gutiérrez, Joaquín José (American Society for Biochemistry and Molecular Biology Inc., 1997)
The moderate halophile Halomonas elongata Deustche Sommlung fur Mikroorganismen 3043 accumulated ectoine, hydroxyectoine, ...
Article
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Osmoprotectants in Halomonas elongata: High-affinity betaine transport system and choline-betaine pathway

Nieto Gutiérrez, Joaquín José; Cánovas López, David; Vargas Macías, Carmen; Ventosa Ucero, Antonio; Csonka, Laszlo N. (American Society for Microbiology, 1996)
The osmoregulatory pathways of the moderately halophilic bacterium Halomonas elongata DSM 3043 have been investigated. ...
Article
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Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in rhizobium leguminosarum

Delgado, María Jesús; Yeoman, Kay H.; Wu, Guanghui; Vargas Macías, Carmen; Davies, Andrea E.; Poole, Robert K.; Johnston, Andrew W. B.; Downi, J. Allan (American Society for Microbiology, 1995)
Mutants of Rhizobium leguminosarum bv. viciae unable to respire via the cytochrome aa3 pathway were identified by the ...
Article
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Development of a gene reporter system in moderately halophilic bacteria by employing the ice nucleation gene of Pseudomonas syringae

Nieto Gutiérrez, Joaquín José; Vargas Macías, Carmen; Ventosa Ucero, Antonio; Arvanitis, Nikilaos; Tegos, Georgios; Perysinakis, Angelos; Drainas, Constantin (American Society for Microbiology, 1995)
The expression of the ice nucleation gene inaZ of Pseudomonas syringae in several moderate halophiles was investigated to ...
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Identification of a gene encoding a thioredoxin-like product necessary for cytochrome c biosynthesis and symbiotic nitrogen fixation in Rhizobium leguminosarum

Vargas Macías, Carmen; Wu, Guanghui; Davies, Andrea E.; Downie, John Allan (American Society for Microbiology, 1994)
A Tn5-induced mutant of Rhizobium leguminosarum bv. viciae could not form nitrogen-fixing nodules on pea or vetch because ...
Article
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Characterization of a plasmid from moderately halophilic eubacteria

Fernández Castillo, Rosario; Vargas Macías, Carmen; Nieto Gutiérrez, Joaquín José; Ventosa Ucero, Antonio; Ruiz Berraquero, Francisco (1992)
A plasmid has been isolated for the first time from moderately halophilic eubacteria. Halomonas elongata, Halomonrrs ...
PhD Thesis
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Clonación y caracterización de los genes de la nodulación de Rhizobium leguminosarum bv. Phaseoli CIAT899

Vargas Macías, Carmen; Megías Guijo, Manuel (1990)
Como se puede deducir del resumen sobre la genética de la nodulación expuesto en la Introducción de esta Tesis Doctoral, ...