dc.creator | Boccardi, Elena | es |
dc.creator | Philippart, Anahí | es |
dc.creator | Juhasz-Bortuzzo, Judith A. | es |
dc.creator | Beltrán, Ana M. | es |
dc.creator | Novajra, Giorgia | es |
dc.creator | Vitale-Brovarone, Chiara | es |
dc.creator | Spiecker, Erdmann | es |
dc.creator | Boccaccini, Aldo R. | es |
dc.date.accessioned | 2018-01-05T08:20:47Z | |
dc.date.available | 2018-01-05T08:20:47Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Boccardi, E., Philippart, A., Juhasz-Bortuzzo, J.A., Beltrán, A.M., Novajra, G., Vitale-Brovarone, C.,...,Boccaccini, A.R. (2015). Uniform surface modification of 3D Bioglass®-based scaffolds with mesoporous silica particles (McM-41) for enhancing drug delivery capability. Frontiers in Bioengineering and Biotechnology, 3 | |
dc.identifier.issn | 2296-4185 | es |
dc.identifier.issn | ESSN 2296-4185 | es |
dc.identifier.uri | http://hdl.handle.net/11441/68327 | |
dc.description.abstract | The design and characterization of a new family of multifunctional scaffolds based on bioactive glass (BG) of 45S5 composition for bone tissue engineering and drug delivery applications are presented. These BG-based scaffolds are developed via a replication method of polyurethane packaging foam. In order to increase the therapeutic functionality, the scaffolds were coated with mesoporous silica particles (MCM-41), which act as an in situ drug delivery system. These sub-micron spheres are characterized by large surface area and pore volume with a narrow pore diameter distribution. The solution used for the synthesis of the silica mesoporous particles was designed to obtain a high-ordered mesoporous structure and spherical shape – both are key factors for achieving the desired controlled drug release. The MCM-41 particles were synthesized directly inside the BG-based scaffolds, and the drug-release capability of this combined system was evaluated. Moreover, the effect of MCM-41 particle coating on the bioactivity of the BG-based scaffolds was assessed. The results indicate that it is possible to obtain a multifunctional scaffold system characterized by high and interconnected porosity, high bioactivity, and sustained drug delivery capability. | es |
dc.description.sponsorship | EU ITN FP-7 project “GlaCERCo.” | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media | es |
dc.relation.ispartof | Frontiers in Bioengineering and Biotechnology, 3 | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Ordered mesoporosity | es |
dc.subject | Silica | es |
dc.subject | McM-41 | es |
dc.subject | Bioactive glass | es |
dc.subject | Scaffolds | es |
dc.subject | Drug release | es |
dc.subject | Ibuprofen | es |
dc.title | Uniform surface modification of 3D Bioglass®-based scaffolds with mesoporous silica particles (McM-41) for enhancing drug delivery capability | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte | es |
dc.relation.projectID | EU ITN FP-7 | es |
dc.relation.publisherversion | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635563/ | es |
dc.identifier.doi | 10.3389/fbioe.2015.00177 | es |
dc.contributor.group | Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales | es |
idus.format.extent | 12 p. | es |
dc.journaltitle | Frontiers in Bioengineering and Biotechnology | es |
dc.publication.volumen | 3 | es |
dc.identifier.sisius | 20850605 | es |
dc.contributor.funder | European Union (UE). FP7 | |