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H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity

Opened Access H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity

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Autor: Zhou, Yue
Romero Campero, Francisco José
Gómez Zambrano, Ángeles
Turck, Franziska
Calonje Macaya, Mirian
Departamento: Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial
Fecha: 2017
Publicado en: Genome Biology, 18 (69), 1-13.
Tipo de documento: Artículo
Resumen: Background: Polycomb group complexes PRC1 and PRC2 repress gene expression at the chromatin level in eukaryotes. The classic recruitment model of Polycomb group complexes in which PRC2-mediated H3K27 trimethylation recruits PRC1 for H2A monoubiquitination was recently challenged by data showing that PRC1 activity can also recruit PRC2. However, the prevalence of these two mechanisms is unknown, especially in plants as H2AK121ub marks were examined at only a handful of Polycomb group targets. Results: By using genome-wide analyses, we show that H2AK121ub marks are surprisingly widespread in Arabidopsis thaliana, often co-localizing with H3K27me3 but also occupying a set of transcriptionally active genes devoid of H3K27me3. Furthermore, by profiling H2AK121ub and H3K27me3 marks in atbmi1a/b/c, clf/swn, and lhp1 mutants we found that PRC2 activity is not required for H2AK121ub marking at most genes. In contrast, loss of AtBMI1 function impacts the incorporation of H3K27...
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Cita: Zhou, Y., Romero Campero, F.J., Gómez Zambrano, Á., Turck, y Calonje Macaya, M. (2017). H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity. Genome Biology, 18 (69), 1-13.
Tamaño: 2.008Mb
Formato: PDF

URI: http://hdl.handle.net/11441/68195

DOI: 10.1186/s13059-017-1197-z

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