Repositorio de producción científica de la Universidad de Sevilla

Modelling gene expression control using P systems: The Lac Operon, a case study

Opened Access Modelling gene expression control using P systems: The Lac Operon, a case study

Citas

buscar en

Estadísticas
Icon
Exportar a
Autor: Romero Campero, Francisco José
Pérez Jiménez, Mario de Jesús
Departamento: Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial
Fecha: 2008
Publicado en: BioSystems, 91 (3), 438-457.
Tipo de documento: Artículo
Resumen: In this paper P systems are used as a formal framework for the specification and simulation of biological systems. In particular, we will deal with gene regulation systems consisting of protein–protein and protein–DNA interactions that take place in different compartments of the hierarchical structure of the living cell or in different individual cells from a colony. We will explicitly model transcription and translation as concurrent and discrete processes using rewriting rules on multisets of objects and strings. Our approach takes into account the discrete character of the components of the system, its random behaviour and the key role played by membranes in processes involving signalling at the cell surface and selective uptake of substances from the environment. Our systems will evolve according to an extension of Gillespie’s algorithm, called Multicompartmental Gillespie’s Algorithm. The well known gene regulation system in the Lac Operon in Escherichia coli will be model...
[Ver más]
Cita: Romero Campero, F.J. y Pérez Jiménez, M.d.J. (2008). Modelling gene expression control using P systems: The Lac Operon, a case study. BioSystems, 91 (3), 438-457.
Tamaño: 791.7Kb
Formato: PDF

URI: http://hdl.handle.net/11441/68002

DOI: 10.1016/j.biosystems.2007.02.011

Ver versión del editor

Mostrar el registro completo del ítem


Esta obra está bajo una Licencia Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internacional

Este registro aparece en las siguientes colecciones