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Zur (FurB) is a key factor in the control of the oxidative stress response in Anabaena sp. PCC 7120

Opened Access Zur (FurB) is a key factor in the control of the oxidative stress response in Anabaena sp. PCC 7120

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Autor: Sein-Echaluce, Violeta C.
González, Andrés
Napolitano, Mauro
Luque, Ignacio
Barja, Francisco
Peleato, M.L.
Fillat, M.F.
Fecha: 2015
Publicado en: Environmental Microbiology, 17 (6), 2006-2017.
Tipo de documento: Artículo
Resumen: Iron and zinc are necessary nutrients whose homeostasis is tightly controlled by members of the ferric uptake regulator (FUR) superfamily in the cyanobacterium Anabaena sp. PCC7120. Although the link between iron metabolism and oxidative stress management is well documented, little is known about the connection between zinc homeostasis and the oxidative stress response in cyanobacteria. Zinc homeostasis in Anabaena is controlled by Zur, also named FurB. When overexpressed in Escherichia coli, Zur (FurB) improved cell survival during oxidative stress. In order to investigate the possible correlation between Zur and the oxidative stress response in Anabaena, zur deletion and zur-overexpressing strains have been constructed, and the consequences of Zur imbalance evaluated. The lack of Zur increased sensitivity to hydrogen peroxide (H2 O2 ), whereas an excess of Zur enhanced oxidative stress resistance. Both mutants displayed pleiotropic phenotypes, including alterations on the filament s...
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Cita: Sein-Echaluce, V.C., González, A., Napolitano, M., Luque, I., Barja, F., Peleato, M.L. y Fillat, M.F. (2015). Zur (FurB) is a key factor in the control of the oxidative stress response in Anabaena sp. PCC 7120. Environmental Microbiology, 17 (6), 2006-2017.
Tamaño: 1014.Kb
Formato: PDF

URI: http://hdl.handle.net/11441/65582

DOI: 10.1111/1462-2920.12628

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