Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes

García Luque, Isabel; Ballesta, Sofía; Murillo del Castillo, Concepción; Perea Pérez, Evelio José; Pascual Hernández, Álvaro

doi:10.1128/AAC.00427-06

Artículo

dc.creator	García Luque, Isabel	es
dc.creator	Ballesta, Sofía	es
dc.creator	Murillo del Castillo, Concepción	es
dc.creator	Perea Pérez, Evelio José	es
dc.creator	Pascual Hernández, Álvaro	es
dc.date.accessioned	2017-10-04T17:11:32Z
dc.date.available	2017-10-04T17:11:32Z
dc.date.issued	2006-09-01
dc.identifier.citation	García Luque, I., Ballesta, S., Murillo del Castillo, C., Perea Pérez, E.J. y Pascual Hernández, Á. (2006). Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes. Antimicrobial Agents and Chemotherapy, 50 (9), 3173-3174.
dc.identifier.issn	0066-4804 (impreso)	es
dc.identifier.issn	1098-6596 (electrónico)	es
dc.identifier.uri	http://hdl.handle.net/11441/65016
dc.description.abstract	The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 reached intracellular concentrations 10 times higher than the extracellular concentrations reached. Uptake was rapid, reversible, nonsaturable, and affected by environmental temperature, some metabolic inhibitors, and a soluble membrane activator. DX-619 showed intracellular activity against Staphylococcus aureus.	es
dc.format	application/pdf	es
dc.language.iso	eng	es
dc.publisher	American Society for Microbiology	es
dc.relation.ispartof	Antimicrobial Agents and Chemotherapy, 50 (9), 3173-3174.
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.title	Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes	es
dc.type	info:eu-repo/semantics/article	es
dcterms.identifier	https://ror.org/03yxnpp24
dc.type.version	info:eu-repo/semantics/publishedVersion	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es
dc.contributor.affiliation	Universidad de Sevilla. Departamento de Microbiología	es
dc.contributor.affiliation	Universidad de Sevilla. Departamento de Estomatología	es
dc.relation.publisherversion	http://dx.doi.org/10.1128/AAC.00427-06	es
dc.identifier.doi	10.1128/AAC.00427-06	es
idus.format.extent	2 p.	es
dc.journaltitle	Antimicrobial Agents and Chemotherapy	es
dc.publication.volumen	50	es
dc.publication.issue	9	es
dc.publication.initialPage	3173	es
dc.publication.endPage	3174	es

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