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Inhibitor-resistant TEM- And OXA-1-producing Escherichia coli isolates resistant to amoxicillin-clavulanate are more clonal and possess lower virulence gene content than susceptible clinical isolates

Opened Access Inhibitor-resistant TEM- And OXA-1-producing Escherichia coli isolates resistant to amoxicillin-clavulanate are more clonal and possess lower virulence gene content than susceptible clinical isolates

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Autor: Otero, Jesús
Conejo Gonzalo, Mª Carmen
González López, Juan José
Ortega, Adriana
Bou, Germán
Cercenado, Emilia
Martínez Martínez, Luis
Navarro, Ferrán
Departamento: Universidad de Sevilla. Departamento de Microbiología
Fecha: 2014-01-01
Publicado en: Antimicrobial Agents and Chemotherapy, 58 (7), 3874-3881.
Tipo de documento: Artículo
Resumen: In a previous prospective multicenter study in Spain, we found that OXA-1 and inhibitor-resistant TEM (IRT) β-lactamases constitute the most common plasmid-borne mechanisms of genuine amoxicillin-clavulanate (AMC) resistance in Escherichia coli. In the present study, we investigated the population structure and virulence traits of clinical AMC-resistant E. coli strains expressing OXA-1 or IRT and compared these traits to those in a control group of clinical AMC-susceptible E. coli isolates. All OXA-1-producing (n = 67) and IRT-producing (n = 45) isolates were matched by geographical and temporal origin to the AMC-susceptible control set (n = 56). We performed multilocus sequence typing and phylogenetic group characterization for each isolate and then studied the isolates for the presence of 49 virulence factors (VFs) by PCR and sequencing. The most prevalent clone detected was distinct for each group: group C isolates of sequence type (ST) 88 (C/ST88) were the most common in OXA-1 pro...
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Cita: Otero, J., Conejo Gonzalo, M.C., González López, J.J., Ortega, A., Bou, G., Cercenado, E.,...,Navarro, F. (2014). Inhibitor-resistant TEM- And OXA-1-producing Escherichia coli isolates resistant to amoxicillin-clavulanate are more clonal and possess lower virulence gene content than susceptible clinical isolates. Antimicrobial Agents and Chemotherapy, 58 (7), 3874-3881.
Tamaño: 239.4Kb
Formato: PDF

URI: http://hdl.handle.net/11441/65015

DOI: 10.1128/AAC.02738-13

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