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Uptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cells

dc.creatorPascual Hernández, Álvaroes
dc.creatorBallesta Mudarra, Sofíaes
dc.creatorGarcía Luque, Isabeles
dc.creatorPerea Pérez, Evelio Josées
dc.date.accessioned2017-10-04T16:45:17Z
dc.date.available2017-10-04T16:45:17Z
dc.date.issued2002-12-01
dc.identifier.citationPascual Hernández, Á., Ballesta Mudarra, S., García Luque, I. y Perea Pérez, E.J. (2002). Uptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cells. Antimicrobial Agents and Chemotherapy, 46 (12), 4013-4015.
dc.identifier.issn0066-4804 (impreso)es
dc.identifier.issn1098-6596 (electrónico)es
dc.identifier.urihttp://hdl.handle.net/11441/65004
dc.description.abstractThe intracellular penetration and activity of linezolid in human polymorphonuclear leukocytes and tissue-cultured cells (McCoy) were evaluated. Linezolid reached intracellular concentrations slightly greater than extracellular ones in both types of cell. The uptake was rapid and not saturable and was affected by environmental temperature and cell viability. Linezolid showed slight intracellular activity against Staphylococcus epidermidis at high extracellular concentrations.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Society for Microbiologyes
dc.relation.ispartofAntimicrobial Agents and Chemotherapy, 46 (12), 4013-4015.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleUptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cellses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Microbiologíaes
dc.relation.publisherversionhttp://dx.doi.org/10.1128/AAC.46.12.4013-4015.2002es
dc.identifier.doi10.1128/AAC.46.12.4013-4015.2002es
idus.format.extent3 p.es
dc.journaltitleAntimicrobial Agents and Chemotherapyes
dc.publication.volumen46es
dc.publication.issue12es
dc.publication.initialPage4013es
dc.publication.endPage4015es

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