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Molecular Epidemiology of Mycobacterium tuberculosis Strains Isolated during a 3-Year Period (1993 to 1995) in Seville, Spain

Opened Access Molecular Epidemiology of Mycobacterium tuberculosis Strains Isolated during a 3-Year Period (1993 to 1995) in Seville, Spain
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Autor: Safi, Hassan
Aznar Martín, Javier
Palomares Folía, José Carlos
Departamento: Universidad de Sevilla. Departamento de Microbiología
Fecha: 1997
Publicado en: Journal of Clinical Microbiology, 35 (10), 2474-2476.
Tipo de documento: Artículo
Resumen: The genetic polymorphism of Mycobacterium tuberculosis strains isolated in Seville, Spain, was studied by using computer-assisted analysis of the IS6110 fingerprint in order to determine the current situation and to evaluate the human-to-human transmission of this pathogen. One hundred seventy-six isolates from 175 patients among the 205 patients diagnosed with tuberculosis (TB) during a 3-year period (1993 to 1995) were cultured and analyzed. One hundred nine patients (62%) were infected with genetically different isolates, and 67 isolates (38%) were grouped into 19 clusters. These results demonstrate that the level of clustering of strains in Seville is intermediate between those in developed and developing countries. Epidemiological relatedness was shown for isolates from only 10 of these clusters. Active and high transmission rates exist in children and in human immunodeficiency virus (HIV)-infected adults, while in non-HIV-infected adults this transmission rate is moderate. Altho...
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Cita: Safi, H., Aznar Martín, J. y Palomares Folia, J.C. (1997). Molecular Epidemiology of Mycobacterium tuberculosis Strains Isolated during a 3-Year Period (1993 to 1995) in Seville, Spain. Journal of Clinical Microbiology, 35 (10), 2474-2476.
Tamaño: 254.7Kb
Formato: PDF

URI: http://hdl.handle.net/11441/64868

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