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N-acetylcysteine selectively antagonizes the activity of imipenem in Pseudomonas aeruginosa by an OprD-mediated mechanism

 

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Opened Access N-acetylcysteine selectively antagonizes the activity of imipenem in Pseudomonas aeruginosa by an OprD-mediated mechanism
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Author: Rodríguez Beltrán, Jerónimo
Cabot, Gabriel
Ynés Valencia, Estela
Costas, Coloma
Bou, Germán
Oliver, Antonio
Blázquez, Jesús
Department: Universidad de Sevilla. Departamento de Microbiología
Date: 2015-01-01
Published in: Antimicrobial Agents and Chemotherapy, 59 (6), 3246-3251.
Document type: Article
Abstract: The modulating effect of N-acetylcysteine (NAC) on the activity of different antibiotics has been studied in Pseudomonas aeruginosa. Our results demonstrate that, in contrast to previous reports, only the activity of imipenem is clearly affected by ...
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Cite: Rodríguez Beltrán, J., Cabot, G., Ynés Valencia, E., Costas, C., Bou, G., Oliver, A. y Blázquez, J. (2015). N-acetylcysteine selectively antagonizes the activity of imipenem in Pseudomonas aeruginosa by an OprD-mediated mechanism. Antimicrobial Agents and Chemotherapy, 59 (6), 3246-3251.
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URI: http://hdl.handle.net/11441/64837

DOI: 10.1128/AAC.00017-15

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