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Population pharmacokinetics of colistin: implications for clinical use for Gram-negative pathogens

 

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Opened Access Population pharmacokinetics of colistin: implications for clinical use for Gram-negative pathogens
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Author: Pachón Ibáñez, María Eugenia
Docobo Pérez, Fernando Manuel
Blanquero Bravo, Rafael
Garnacho Montero, José
Benítez Peña, Sandra
Dimopoulos, George
Rosso Fernández, Clara
Gutiérrez Pizarraya, Antonio
López Cortés, Luis Fernando
Cisneros Herreros, José Miguel
Department: Universidad de Sevilla. Departamento de Estadística e Investigación Operativa
Date: 2016
Document type: Presentation
Abstract: The objective of this study was to characterize the pharmacokinetics of colistin methanesulphonate (CMS) and colistin in critically ill patients following the administration of a 4.5 MU CMS loading dose follow by 3MU CMS Q8. A population PK model and Monte Carlo simulation were used to calculate the probability of target attainment (PTA) against Acinetobacter baumannii and Pseudomonas aeruginosa by considering a range of MIC values seen in the clinic.
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URI: http://hdl.handle.net/11441/64282

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