Data

NameDocobo Pérez, Fernando
DepartmentMicrobiología
Knowledge areaMicrobiología
Professional categoryProfesor Contratado Doctor
E-mailRequest
           

  Statistics

  • Items

    13

  • Visits

    1573

  • Downloads

    2646

  Publications

 

PhD Thesis
Icon

Heterorresistencia a fosfomicina en Escherichia coli: bases moleculares y efecto en su potencial terapéutico

Docobo Pérez, Fernando; Pascual Hernández, Álvaro; Portillo Calderón, Inés María (2022-03-15)
En las últimas décadas, el aumento progresivo de la resistencia a los antimicrobianos se ha convertido en un problema ...
Article
Icon

Effect of RecA inactivation and detoxification systems on the evolution of ciprofloxacin resistance in Escherichia coli

Díaz Díaz, S.; Recacha Villamor, Esther; García Duque, A.; Docobo Pérez, Fernando; Blázquez, J. (Oxford University Press, 2022-01-01)
Background Suppression of SOS response and overproduction of reactive oxygen species (ROS) through detoxification system ...
Article
Icon

Population pharmacokinetics of piperacillin in non-critically ill patients with bacteremia caused by enterobacteriaceae

Merino Bohórquez, Vicente; Docobo Pérez, Fernando; Valiente-Méndez, Adoración; Delgado-Valverde, Mercedes; Cameán, Manuel; Hope, William W.; Rodríguez-Baño, Jesús (MDPI, 2021-03-25)
This study analyzes the pharmacokinetic variability of piperacillin in non-critically ill patients with Enterobacteriaceae ...
Article
Icon

Disbalancing Envelope Stress Responses as a Strategy for Sensitization of Escherichia coli to Antimicrobial Agents

Recacha Villamor, Esther; Fox, Valeria; Díaz Díaz, Sara; García Duque, Ana; Docobo Pérez, Fernando; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel (Frontiers Media, 2021-01-01)
Disbalancing envelope stress responses was investigated as a strategy for sensitization of Escherichia coli to antimicrobial ...
Article
Icon

Detection of low-level fosfomycin-resistant variants by decreasing glucose-6-phosphate concentration in fosfomycin susceptibility determination

Martín-Gutiérrez, Guillermo; Docobo Pérez, Fernando; Rodríguez Martínez, José Manuel; Pascual Hernández, Álvaro; Blázquez, Jesús; Rodríguez Beltrán, Jerónimo (Multidisciplinary Digital Publishing Institute (MDPI), 2020-01-01)
Mutations that confer low-level fosfomycin resistance (LLFR) but not clinical resistance in Escherichia coli are increasingly ...
PhD Thesis
Icon

Bases moleculares de la resistencia a fosfomicina e implicación de las subpoblaciones con sensibilidad disminuida en su actividad in vitro.

Pascual Hernández, Álvaro; Docobo Pérez, Fernando; Ballestero Téllez, Mónica (2018-01-18)
El interés global que existe actualmente, en recuperar antibióticos antiguos para el tratamiento de infecciones causadas ...
Article
Icon

Quinolone Resistance Reversion by Targeting the SOS Response

Recacha, E.; Machuca, J.; Díaz Alba, P.; Docobo Pérez, Fernando; Rodríguez Beltrán, Jerónimo; Rodríguez Martínez, José Manuel (American Society for Microbiology, 2017-01-01)
Suppression of the SOS response has been postulated as a therapeutic strategy for potentiating antimicrobial agents. We ...
Presentation
Icon

Population pharmacokinetics of colistin: implications for clinical use for Gram-negative pathogens

Pachón Ibáñez, María Eugenia; Docobo Pérez, Fernando; Blanquero Bravo, Rafael; Garnacho Montero, José; Benítez Peña, Sandra; Dimopoulos, George; Rosso Fernández, Clara; Gutiérrez Pizarraya, Antonio; López Cortés, Luis Fernando; Cisneros Herreros, José Miguel (2016-01-01)
The objective of this study was to characterize the pharmacokinetics of colistin methanesulphonate (CMS) and colistin in ...
Article
Icon

Pharmacodynamics of fosfomycin: Insights into clinical use for antimicrobial resistance

Rodríguez Martínez, José Manuel; Conejo Gonzalo, Mª Carmen; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Docobo Pérez, Fernando (American Society for Microbiology, 2015-09-01)
The aim of this study was to improve the understanding of the pharmacokinetic-pharmacodynamic relationships of fosfomycin ...
Article
Icon

Inoculum Effect on the Efficacies of Amoxicillin-Clavulanate, Piperacillin-Tazobactam, and Imipenem against Extended-Spectrum -Lactamase (ESBL)-Producing and Non-ESBL-Producing Escherichia coli in an Experimental Murine Sepsis Model

Docobo Pérez, Fernando; López Cerero, Lorena; López-Rojas, Rafael; Egea, P.; Domínguez-Herrera, J.; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Pachón Díaz, Jerónimo (American Society for Microbiology, 2013-04-01)
Escherichia coli is commonly involved in infections with a heavy bacterial burden. Piperacillin-tazobactam and carbapenems ...
Article
Icon

Platelet-activating Factor Receptor Initiates Contact of Acinetobacter baumannii Expressing Phosphorylcholine with Host Cells

Smani, Younes; Docobo Pérez, Fernando; López Rojas, Rafael; Domínguez Herrera, Juan; Ibáñez Martínez, José; Pachón Díaz, Jerónimo (2012-06-01)
Adhesion is an initial and important step in Acinetobacter baumannii causing infections. However, the exact molecular ...
Article
Icon

Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii

López-Rojas, Rafael; Domínguez-Herrera, J.; Mcconnell, Michael; Docobo Pérez, Fernando; Smani, Younes; Pachón Díaz, Jerónimo (Oxford University Press, 2011-01-07)
Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in ...
PhD Thesis
Icon

Tratamientos de la neumonía experimental por Staphylococcus aureus : estudios de eficacia terapéutica de cotrimoxazol, cloxacilina, linezolid y vancomicina frente a cepas S. aureus sensible y resistente a meticilina

Pachón Díaz, Jerónimo; Docobo Pérez, Fernando (2009-01-01)
El objetivo general de este proyecto es comparar la actividad de cotrimoxazol, vancomicina, linezolid y cloxacilina ...