Presentation
Population pharmacokinetics of colistin: implications for clinical use for Gram-negative pathogens
Author/s | Pachón Ibáñez, María Eugenia
Docobo Pérez, Fernando ![]() ![]() ![]() ![]() ![]() ![]() ![]() Blanquero Bravo, Rafael ![]() ![]() ![]() ![]() ![]() ![]() ![]() Garnacho Montero, José Benítez Peña, Sandra Dimopoulos, George Rosso Fernández, Clara Gutiérrez Pizarraya, Antonio López Cortés, Luis Fernando ![]() ![]() ![]() ![]() ![]() ![]() Cisneros Herreros, José Miguel |
Department | Universidad de Sevilla. Departamento de Estadística e Investigación Operativa |
Date | 2016 |
Published in |
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Abstract | The objective of this study was to characterize the pharmacokinetics of colistin methanesulphonate (CMS) and colistin in critically ill patients
following the administration of a 4.5 MU CMS loading dose follow by 3MU CMS ... The objective of this study was to characterize the pharmacokinetics of colistin methanesulphonate (CMS) and colistin in critically ill patients following the administration of a 4.5 MU CMS loading dose follow by 3MU CMS Q8. A population PK model and Monte Carlo simulation were used to calculate the probability of target attainment (PTA) against Acinetobacter baumannii and Pseudomonas aeruginosa by considering a range of MIC values seen in the clinic. |
Citation | Pachón Ibáñez, M.E., Docobo Pérez, F., Blanquero Bravo, R., Garnacho Montero, J., Benítez Peña, S., Dimopoulos, G.,...,Cisneros Herreros, J.M. (2016). Population pharmacokinetics of colistin: implications for clinical use for Gram-negative pathogens. En 26th European Congress of Clinical Microbiology and Infectious Diseases, Amsterdam. |
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