Repositorio de producción científica de la Universidad de Sevilla

Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection

Opened Access Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection

Citas

buscar en

Estadísticas
Icon
Exportar a
Autor: Ribeiro Viana, Renato
Sánchez Navarro, Macarena
Luczkowiak, Joanna
Koeppe, Julia R.
Rojo, Javier
Fecha: 2012
Publicado en: Nature Communications, 3 (1303), 1-8.
Tipo de documento: Artículo
Resumen: Ligand polyvalency is a powerful modulator of protein–receptor interactions. Host–pathogen infection interactions are often mediated by glycan ligand–protein interactions, yet its interrogation with very high copy number ligands has been limited to heterogenous systems. Here we report that through the use of nested layers of multivalency we are able to assemble the most highly valent glycodendrimeric constructs yet seen (bearing up to 1,620 glycans). These constructs are pure and well-defined single entities that at diameters of up to 32 nm are capable of mimicking pathogens both in size and in their highly glycosylated surfaces. Through this mimicry these glyco-dendri-protein-nano-particles are capable of blocking (at picomolar concentrations) a model of the infection of T-lymphocytes and human dendritic cells by Ebola virus. The high associated polyvalency effects (β>106, β/N ~102–103) displayed on an unprecedented surface area by precise clusters suggest a general strategy for modu...
[Ver más]
Cita: Ribeiro Viana, R., Sánchez Navarro, M., Luczkowiak, J., Koeppe, J.R. y Rojo, J. (2012). Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection. Nature Communications, 3 (1303), 1-8.
Tamaño: 1.616Mb
Formato: PDF

URI: http://hdl.handle.net/11441/64051

DOI: 10.1038/ncomms2302

Ver versión del editor

Mostrar el registro completo del ítem


Esta obra está bajo una Licencia Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internacional

Este registro aparece en las siguientes colecciones