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Role of trehalose in growth at high temperature of Salmonella enterica serovar typhimurium

Opened Access Role of trehalose in growth at high temperature of Salmonella enterica serovar typhimurium

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Autor: Cánovas López, David
Fletcher, Susanne A.
Hayashi, Mikachi
Csonka, Laszlo N.
Departamento: Universidad de Sevilla. Departamento de Microbiología y Parasitología
Fecha: 2001-06
Publicado en: Journal of Bacteriology, 183 (11), 3365-3371.
Tipo de documento: Artículo
Resumen: Moderate osmolality can stimulate bacterial growth at temperatures near the upper limit for growth. We investigated the mechanism by which high osmolality enhances the thermotolerance of Salmonella enterica serovar Typhimurium, by isolating bacteriophage MudI1734-induced insertion mutations that blocked the growth-stimulatory effect of 0.2 M NaCl at 45°C. One of these mutations proved to be in the seqA gene (a regulator of initiation of DNA synthesis). Because this gene is cotranscribed with pgm (which encodes phosphoglucomutase), it is likely to be polar on the expression of the pgm gene. Pgm catalyzes the conversion of glucose-6-phosphate to glucose-1-phosphate during growth on glucose, and therefore loss of Pgm results in a deficiency in a variety of cellular constituents derived from glucose-1-phosphate, including trehalose. To test the possibility that the growth defect of the seqA::MudI1734 mutant at high temperature in medium of high osmolality is due to the block in trehalose ...
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Cita: Cánovas López, D., Fletcher, S.A., Hayashi, M. y Csonka, L.N. (2001). Role of trehalose in growth at high temperature of Salmonella enterica serovar typhimurium. Journal of Bacteriology, 183 (11), 3365-3371.
Tamaño: 123.8Kb
Formato: PDF

URI: http://hdl.handle.net/11441/62997

DOI: 10.1128/JB.183.11.3365-3371.2001

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