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Arsenic sensing and resistance system in the cyanobacterium Synechocystis sp. Strain PCC 6803

Opened Access Arsenic sensing and resistance system in the cyanobacterium Synechocystis sp. Strain PCC 6803

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Autor: López Maury, Luis
Florencio Bellido, Francisco Javier
Reyes Rosa, José Carlos
Departamento: Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
Fecha: 2003-09
Publicado en: Journal of Bacteriology, 185 (18), 5363-5371.
Tipo de documento: Artículo
Resumen: Arsenic is one of the most important global environmental pollutants. Here we show that the cyanobacterium Synechocystis sp. strain PCC 6803 contains an arsenic and antimony resistance operon consisting of three genes: arsB, encoding a putative arsenite and antimonite carrier, arsH, encoding a protein of unknown function, and arsC, encoding a putative arsenate reductase. While arsB mutant strains were sensitive to arsenite, arsenate, and antimonite, arsC mutants were sensitive only to arsenate. The arsH mutant strain showed no obvious phenotype under the conditions tested. In vivo the arsBHC operon was derepressed by oxyanions of arsenic and antimony (oxidation state, +3) and, to a lesser extent, by bismuth (oxidation state, +3) and arsenate (oxidation state, +5). In the absence of these effectors, the operon was repressed by a transcription repressor of the ArsR/SmtB family, encoded by an unlinked gene termed arsR. Thus, arsR null mutants showed constitutive derepression of the arsBH...
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Cita: López Maury, L., Florencio Bellido, F.J. y Reyes Rosa, J.C. (2003). Arsenic sensing and resistance system in the cyanobacterium Synechocystis sp. Strain PCC 6803. Journal of Bacteriology, 185 (18), 5363-5371.
Tamaño: 1.046Mb
Formato: PDF

URI: http://hdl.handle.net/11441/62954

DOI: 10.1128/JB.185.18.5363-5371.2003

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