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Alpha-synuclein and immune system crosstalk in parkinson's disease; therapeutic approaches of its modulation by molecular chaperones

Opened Access Alpha-synuclein and immune system crosstalk in parkinson's disease; therapeutic approaches of its modulation by molecular chaperones
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Autor: Labrador Garrido, Adahir
Director: Roodveldt, Cintia
Pozo Pérez, David
Departamento: Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología
Fecha: 2017-05-22
Tipo de documento: Tesis Doctoral
Resumen: This Doctoral Thesis is focused on the interplay between the immune system and the Parkinson’s related protein alpha-Synuclein. The first part of this work was to study the impact of extracellular aSyn priming on the microglial innate immune response following TLR stimulation. As a result we found that extracellular non-aggregated alpha-synuclein could potentially act as a priming factor for microglia to produce exacerbated TLR7 and TLR1/2 responses upon further challenge as compared to the same challenge in the absence of such priming. The second part of my PhD study was centred in testing immunotherapeutic approaches for Parkinson’s Disease. During the last decade, it has become accepted that there is a link between alpha-synuclein and the sustained neuroinflammation and immune imbalance associated to Parkinson’s disease. As a result, different approximations have been tested to try to restore it. Molecular chaperones have a key role in preventing abnormal protein aggregation by i...
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Cita: Labrador Garrido, A. (2017). Alpha-synuclein and immune system crosstalk in parkinson's disease; therapeutic approaches of its modulation by molecular chaperones. (Tesis Doctoral Inédita). Universidad de Sevilla, Sevilla.
Tamaño: 15.20Mb
Formato: PDF

URI: http://hdl.handle.net/11441/61143

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