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Neural correlates of alerting and orienting impairment in multiple sclerosis patients

 

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dc.creator Vázquez Marrufo, Manuel es
dc.creator Galvao Carmona, Alejandro es
dc.creator González Rosa, Javier es
dc.creator Hidalgo Muñoz, Antonio Rafael es
dc.creator Borges, Mónica es
dc.creator Ruiz Peña, Juan L. es
dc.creator Izquierdo Ayuso, Guillermo es
dc.date.accessioned 2017-06-06T07:17:50Z
dc.date.available 2017-06-06T07:17:50Z
dc.date.issued 2014
dc.identifier.citation Vázquez Marrufo, M., Galvao Carmona, A., González Rosa, J., Hidalgo Muñoz, A.R., Borges, M., Ruiz Peña, J.L. y Izquierdo Ayuso, G. (2014). Neural correlates of alerting and orienting impairment in multiple sclerosis patients. PLOS One, 9 (5)
dc.identifier.issn 1932-6203 es
dc.identifier.uri http://hdl.handle.net/11441/60971
dc.description.abstract Background A considerable percentage of multiple sclerosis patients have attentional impairment, but understanding its neurophysiological basis remains a challenge. The Attention Network Test allows 3 attentional networks to be studied. Previous behavioural studies using this test have shown that the alerting network is impaired in multiple sclerosis. The aim of this study was to identify neurophysiological indexes of the attention impairment in relapsing-remitting multiple sclerosis patients using this test. Results After general slowing had been removed in patients group to isolate the effects of each condition, some behavioral differences between them were obtained. About Contingent Negative Variation, a statistically significant decrement were found in the amplitude for Central and Spatial Cue Conditions for patient group (p<0.05). ANOVAs showed for the patient group a significant latency delay for P1 and N1 components (p<0.05) and a decrease of P3 amplitude for congruent and incongruent stimuli (p<0.01). With regard to correlation analysis, PASAT-3s and SDMT showed significant correlations with behavioral measures of the Attention Network Test (p<0.01) and an ERP parameter (CNV amplitude). Conclusions Behavioral data are highly correlated with the neuropsychological scores and show that the alerting and orienting mechanisms in the patient group were impaired. Reduced amplitude for the Contingent Negative Variation in the patient group suggests that this component could be a physiological marker related to the alerting and orienting impairment in relapsing-remitting multiple sclerosis. P1 and N1 delayed latencies are evidence of the demyelination process that causes impairment in the first steps of the visual sensory processing. Lastly, P3 amplitude shows a general decrease for the pathological group probably indexing a more central impairment. These results suggest that the Attention Network Test give evidence of multiple levels of attention impairment, which could help in the assessment and treatment of relapsing-remitting multiple sclerosis patients. es
dc.description.sponsorship Ministerio de Economía y Competitividad de España PSI2010-16825 es
dc.description.sponsorship Asociación Neuroinvest es
dc.description.sponsorship Asociación Sanitaria Virgen Macarena es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Public Library of Science es
dc.relation.ispartof PLOS One, 9 (5)
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.title Neural correlates of alerting and orienting impairment in multiple sclerosis patients es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Psicología Experimental es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Medicina es
dc.relation.projectID info:eu-repo/grantAgreement/MINECO/PSI2010-16825 es
dc.relation.publisherversion https://doi.org/10.1371/journal.pone.0097226 es
dc.identifier.doi 10.1371/journal.pone.0097226 es
idus.format.extent 13 p. es
dc.journaltitle PLOS One es
dc.publication.volumen 9 es
dc.publication.issue 5 es
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