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Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma

 

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dc.creator Cordero Morales, Mario David es
dc.creator Alcocer-Gómez, Elísabet es
dc.creator Cano García, Francisco Javier es
dc.creator Miguel Rodríguez, Manuel de es
dc.creator Carrion Rodriguez, Angel es
dc.creator Navas Lloret, Plácido es
dc.creator Sánchez Alcázar, José Antonio es
dc.date.accessioned 2017-02-15T19:09:37Z
dc.date.available 2017-02-15T19:09:37Z
dc.date.issued 2011
dc.identifier.citation Cordero Morales, M.D., Alcocer-Gómez, E., Cano García, F.J., Miguel Rodríguez, M.d., Carrion Rodriguez, A., Navas Lloret, P. y Sánchez Alcázar, J.A. (2011). Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma. Plos One, 6 (10), 1-6.
dc.identifier.issn 1932-6203 es
dc.identifier.uri http://hdl.handle.net/11441/54225
dc.description.abstract Background: We examined lipid peroxidation (LPO) in blood mononuclear cells (BMCs) and plasma, as a marker of oxidative damage, and its association to clinical symptoms in Fibromyalgia (FM) patients. Methods: We conducted a case–control and correlational study comparing 65 patients and 45 healthy controls. Clinical parameters were evaluated using the Fibromyalgia Impact Questionnaire (FIQ), visual analogues scales (VAS), and the Beck Depression Inventory (BDI). Oxidative stress was determined by measuring LPO in BMCs and plasma. Results: We found increased LPO levels in BMCs and plasma from FM patients as compared to normal control (P<0.001). A significant correlation between LPO in BMCs and clinical parameters was observed (r = 0.584, P<0.001 for VAS; r = 0.823, P<0.001 for FIQ total score; and r = 0.875, P<0.01 for depression in the BDI). We also found a positive correlation between LPO in plasma and clinical symptoms (r = 0.452, P<0.001 for VAS; r = 0.578, P<0.001 for FIQ total score; and r = 0.579, P<0.001 for depression in the BDI). Partial correlation analysis controlling for age and BMI, and sex, showed that both LPO in cells and plasma were independently associated to clinical symptoms. However, LPO in cells, but not LPO in plasma, was independently associated to clinical symptoms when controlling for depression (BDI scores). Discussion: The results of this study suggest a role for oxidative stress in the pathophysiology of fibromyalgia and that LPO in BMCs rather than LPO in plasma is better associated to clinical symptoms in FM. es
dc.description.sponsorship Ministerio de Sanidad FIS PI080500 es
dc.description.sponsorship Federación Andaluza de Fibromialgia y Fatiga Crónica FIS EC08/00076 es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Public Library of Science es
dc.relation.ispartof Plos One, 6 (10), 1-6.
dc.rights Atribución-NoComercial 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ *
dc.title Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Personalidad, Evaluación y Tratamiento Psicológicos es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica es
dc.relation.projectID FIS PI080500 es
dc.relation.projectID FIS EC08/00076 es
dc.relation.publisherversion http://dx.doi.org/10.1371/journal.pone.0026915 es
dc.identifier.doi 10.1371/journal.pone.0026915 es
idus.format.extent 6 p. es
dc.journaltitle Plos One es
dc.publication.volumen 6 es
dc.publication.issue 10 es
dc.publication.initialPage 1 es
dc.publication.endPage 6 es
dc.contributor.funder Ministerio de Sanidad. España
dc.contributor.funder Federación Andaluza de Fibromialgia y Fatiga Crónica
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